SCHEMBL1013267

SCHEMBL1013267

Cn1ncc(OC(=O)O)c1C(F)F

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 3/20 0.32
ITGB7 P26010 3/20 0.32
ACHE P22303 1/20 0.32
ITGB1 P05556 1/20 0.31
HTT P42858 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27956205 0.87 CFD (0.33) ITGA4ITGB7ACHEHTTKDM4E
SCHEMBL1012752 0.80 KMT2A (0.39) ACHEKDM4EALDH1A1
SCHEMBL28046751 0.75 HIF1A (0.31)
SCHEMBL713246 0.74 ALDH1A1 (0.39) ACHEKDM4EALDH1A1
SCHEMBL4970754 0.74 KDM4E (0.35) HTTKDM4EALDH1A1
SCHEMBL2192830 0.70 CYP1A2 (0.40) KDM4EALDH1A1
SCHEMBL11893138 0.69 MGLL (0.36) ACHEHTTALDH1A1
SCHEMBL1012183 0.69 KDM4E (0.36) ITGA4ITGB7ITGB1HTTKDM4E
SCHEMBL15825776 0.69 ATM (0.38) KDM4E
SCHEMBL19327 0.67 KDM4E (0.46) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2158185-B1 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS BASF SE (DE) 2011-08-17 EP disclosed
EP-1644314-B1 METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS BAYER CROPSCIENCE AG (DE) 2011-08-10 EP disclosed
EP-1678119-B1 METHOD FOR PRODUCING 2-DIHALOACYL-3-AMINO-ACRYLIC ACID ESTERS AND 3-DIHALOMETHYL-PYRAZOLE-4-CARBOXYLIC ACID ESTERS BAYER CROPSCIENCE AG (DE) 2011-01-05 EP disclosed
EP-2158185-A2 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS Basf Se (DE) 2010-03-03 EP disclosed
WO-2008152138-A2 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS BASF SE (DE) 2008-12-18 WO disclosed
EP-1644314-A1 METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS Bayer CropScience Aktiengesellschaft (DE) 2006-04-12 EP disclosed
WO-2005003077-A1 METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2005-01-13 WO disclosed