SCHEMBL10145461

SCHEMBL10145461

CC(C)(C)c1cc2oc3cc(=O)c(Cl)cc-3nc2cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
ALPL P05186 1/20 0.38
POLB P06746 1/20 0.38
ALPI P09923 1/20 0.38
MAPT P10636 1/20 0.38
ALPG P10696 1/20 0.38
RECQL P46063 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SNCA P37840 1/20 0.37
APP P05067 4/20 0.33
CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10175953 0.87 SNCA (0.37) LMNAKDM4EMEN1ALDH1A1ALPL
SCHEMBL12714421 0.79 SNCA (0.47) LMNAKDM4EMEN1ALDH1A1ALPL
SCHEMBL10145471 0.76 KDM4E (0.38) LMNAKDM4EMEN1ALDH1A1ALPL
SCHEMBL4447487 0.74 MAPT (0.49) LMNAKDM4EMEN1ALDH1A1ALPL
SCHEMBL9326802 0.73 RAB9A (0.68) KDM4EMEN1ALDH1A1ALPLPOLB
SCHEMBL21130276 0.64 LMNA (0.56) LMNAKDM4EPOLBCYP1A2
SCHEMBL18924199 0.62 L3MBTL1 (0.38) KDM4EMEN1ALDH1A1ALPLPOLB
SCHEMBL16970575 0.61 DHODH (0.49) LMNAKDM4EMEN1ALDH1A1ALPL
SCHEMBL24133258 0.61 LMNA (0.36) LMNARAB9A
SCHEMBL21130273 0.61 LMNA (0.65) LMNAKDM4EALDH1A1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES ROS1, LPO, HMOX1 LMNA 2493/4885KDM4E 3266/4885MEN1 4478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.