Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 11/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153293 | 0.88 | ACHE (0.45) | NPC1RAB9ASMN1; SMN2MAPTKCNK9 | |
| SCHEMBL10153594 | 0.86 | ACHE (0.45) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL10153721 | 0.84 | KDR (0.47) | GRM4KDRMAPT | |
| SCHEMBL9959325 | 0.83 | APP (0.42) | MAPT | |
| SCHEMBL10153305 | 0.83 | MEN1 (0.46) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10153644 | 0.79 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9959247 | 0.79 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10153698 | 0.79 | ALDH1A1 (0.39) | KDM4EMAPT | |
| SCHEMBL9960564 | 0.79 | TRPA1 (0.38) | MAPT | |
| SCHEMBL10153686 | 0.79 | MEN1 (0.46) | NPC1RAB9ASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |