Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.67 |
| ▸ | KDM4A | O75164 | 3/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.67 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.67 |
| ▸ | KDM6B | O15054 | 1/20 | 0.67 |
| ▸ | KDM6A | O15550 | 1/20 | 0.67 |
| ▸ | TET3 | O43151 | 1/20 | 0.67 |
| ▸ | KDM4B | O94953 | 1/20 | 0.67 |
| ▸ | KDM5C | P41229 | 1/20 | 0.67 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.67 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.67 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.67 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.67 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.67 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.67 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.67 |
| ▸ | COMT | P21964 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15170803 | 0.88 | KDM4E (0.63) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL2839557 | 0.84 | KDM4E (0.67) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL27468637 | 0.82 | KDM4E (0.77) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL29349767 | 0.80 | KDM4E (1.00) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL6068195 | 0.80 | KDM4E (1.00) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL7646199 | 0.79 | KDM4E (1.00) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL163474 | 0.79 | KDM4E (0.73) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL29462403 | 0.79 | KDM4E (0.73) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| SCHEMBL7956981 | 0.79 | KDM4E (0.66) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 | |
| Hydrochloric Acid SCHEMBL7650578 | 0.78 | KDM4E (0.97) | KDM4EL3MBTL1KDM4AKDM4CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-20150025085-A1 | Iron Chelators And Uses Thereof | VARINEL INC (US) | 2015-01-22 | — | — | US | disclosed |
| US-20150025085-A1 | Iron Chelators And Uses Thereof | VARINEL INC (US) | 2015-01-22 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20130310346-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2013114296-A1 | IRON CHELATORS AND USES THEREOF | VARINEL INC. (US) | 2013-08-08 | — | — | WO | disclosed |
| WO-2013115793-A1 | IRON CHELATORS AND USES THEREOF | VARINEL, INC. (US) | 2013-08-08 | — | — | WO | disclosed |
| WO-2012020389-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310346-A1 | METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS WITH IRON CHELATORS | FTH1, TFRC, HAMP | KDM4E 979/4885L3MBTL1 1883/4885KDM4A 667/4885 |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | MAOA, MAOB, FECH | KDM4E 183/4885L3MBTL1 1725/4885KDM4A 223/4885 |
| US-20150025085-A1 | Iron Chelators And Uses Thereof | FECH, HDAC8, COQ8A | KDM4E 104/4885L3MBTL1 911/4885KDM4A 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.