Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 7/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10162432 | 0.91 | RIPK1 (0.48) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL10162468 | 0.91 | ROCK2 (0.44) | ROCK2ROCK1KCNN3 | |
| SCHEMBL10162477 | 0.87 | MEN1 (0.50) | KCNN3MAPK14NAMPT | |
| SCHEMBL10162366 | 0.87 | KCNN3 (0.47) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL10161535 | 0.84 | ADAMTS4 (0.46) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL13161093 | 0.84 | ROCK2 (0.43) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL10161742 | 0.84 | ROCK2 (0.43) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL10162187 | 0.83 | KCNN3 (0.46) | ROCK2ROCK1KCNN3MAPK14GLS | |
| SCHEMBL10162483 | 0.83 | POLB (0.47) | ROCK2 | |
| SCHEMBL8225572 | 0.82 | KCNN3 (0.46) | ROCK2ROCK1KCNN3MAPK14GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835441-B2 | Heterobicyclic metalloprotease inhibitors | AMGEN INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-7795245-B2 | Heterobicyclic metalloprotease inhibitors | Atlantos Pharmaceuticals Holding, Inc. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2009-05-28 | — | — | US | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | MMP13, TIMP3, MMP3 | ROCK2 1967/4885ROCK1 2537/4885KCNN3 2625/4885 |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | ROCK2 1967/4885ROCK1 2537/4885KCNN3 2625/4885 |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | ROCK2 1967/4885ROCK1 2537/4885KCNN3 2625/4885 |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | ROCK2 1967/4885ROCK1 2537/4885KCNN3 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.