Sugi Predict

Sugi Predict / Compounds / SCHEMBL10162859

SCHEMBL10162859

SCHEMBL10162859

CC(F)Oc1cccc(CNC(=O)c2cc(C(=O)NCc3ccc4oc(=O)n(C)c4c3)nc3ccnn23)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.39
▸ TP53 P04637 2/20 0.39
▸ IDO1 P14902 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ ATM Q13315 1/20 0.38
▸ CLK1 P49759 1/20 0.38
▸ ROS1 P08922 1/20 0.37
▸ ALK Q9UM73 1/20 0.37
▸ ADAMTS4 O75173 1/20 0.36
▸ MMP3 P08254 1/20 0.36
▸ MMP8 P22894 1/20 0.36
▸ MMP12 P39900 1/20 0.36
▸ MMP13 P45452 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ RECQL P46063 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ KCNN3 Q9UGI6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10162858 0.94 HPGD (0.39) LMNATP53RXFP1CLK1ADAMTS4
SCHEMBL10162869 0.90 ROCK2 (0.41) LMNATP53IDO1RXFP1ATM
SCHEMBL10162861 0.90 ALDH1A1 (0.40) LMNATP53ATMKDM4EALDH1A1
SCHEMBL8225364 0.89 GLS (0.39) LMNATP53IDO1RXFP1CLK1
SCHEMBL8229567 0.89 ROCK2 (0.42) TP53IDO1ADAMTS4MMP3MMP8
SCHEMBL10163505 0.88 MMP13 (0.40) LMNATP53IDO1RXFP1ATM
SCHEMBL10162873 0.88 TP53 (0.44) LMNATP53ADAMTS4MMP3MMP8
SCHEMBL10162848 0.87 POLB (0.48) LMNATP53RXFP1ADAMTS4MMP3
SCHEMBL8228916 0.87 METTL3 (0.38) LMNATP53ADAMTS4MMP3MMP8
SCHEMBL8221132 0.86 DHODH (0.39) LMNATP53RXFP1ADAMTS4MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835441-B2 Heterobicyclic metalloprotease inhibitors AMGEN INC. (US) 2014-09-16 — — US disclosed
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2012-01-19 — — US disclosed
US-7795245-B2 Heterobicyclic metalloprotease inhibitors Atlantos Pharmaceuticals Holding, Inc. (US) 2010-09-14 — — US disclosed
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-12-17 — — US disclosed
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. 2009-05-28 — — US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors MMP13, TIMP3, MMP3 LMNA 2387/4885TP53 3627/4885IDO1 374/4885
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS MMP13, TIMP3, MMP3 LMNA 2387/4885TP53 3627/4885IDO1 374/4885
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 LMNA 2387/4885TP53 3627/4885IDO1 374/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 LMNA 2387/4885TP53 3627/4885IDO1 374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.