Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.81 |
| ▸ | TYMS | P04818 | 3/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | GAA | P10253 | 1/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | DHFR | P00374 | 5/20 | 0.57 |
| ▸ | GART | P22102 | 2/20 | 0.53 |
| ▸ | ATIC | P31939 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12523472 | 1.00 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL470145 | 1.00 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL13575164 | 0.93 | TYMS (0.84) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL13011046 | 0.93 | TYMS (0.84) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL29907321 | 0.92 | AKR1B1 (0.82) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30078340 | 0.92 | TYMS (0.82) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30078194 | 0.91 | TYMS (0.84) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL15094347 | 0.91 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30174303 | 0.91 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL16150298 | 0.91 | AKR1B1 (0.77) | AKR1B1TYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138484-B2 | Conjugates containing hydrophilic spacer linkers | ENDOCYTE, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9138484-B2 | Conjugates containing hydrophilic spacer linkers | ENDOCYTE, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9000135-B2 | Self-reactive arms and prodrugs comprising same | CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) | 2015-04-07 | — | — | US | disclosed |
| US-9000135-B2 | Self-reactive arms and prodrugs comprising same | CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) | 2015-04-07 | — | — | US | disclosed |
| US-20140154702-A1 | Methods For Treating Cancer Using Combination Therapies | ENDOCYTE INC (US) | 2014-06-05 | — | — | US | disclosed |
| US-20140073761-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | ENDOCYTE, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140073761-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | ENDOCYTE, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130144045-A1 | NOVEL SELF-REACTIVE ARMS AND PRODRUGS COMPRISING SAME | UNIVERSITE DE POITIERS (FR) | 2013-06-06 | — | — | US | disclosed |
| US-20130144045-A1 | NOVEL SELF-REACTIVE ARMS AND PRODRUGS COMPRISING SAME | UNIVERSITE DE POITIERS (FR) | 2013-06-06 | — | — | US | disclosed |
| US-20120022245-A1 | FOLATE TARGETING OF NUCLEOTIDES | PURDUE RESEARCH FOUNDATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120022245-A1 | FOLATE TARGETING OF NUCLEOTIDES | PURDUE RESEARCH FOUNDATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-7862798-B2 | vitamin-imaging agent conjugates, that binds to a cell surface vitamin receptor to concentrate a chelated radionuclide on the cell surface, used to target radionuclides to cells, such as tumor cells; medical diagnosis | ENDOCYTE, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| US-20100323973-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | ENDOCTYE, INC. | 2010-12-23 | — | — | US | disclosed |
| US-20100323973-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | ENDOCTYE, INC. | 2010-12-23 | — | — | US | disclosed |
| US-20100104626-A1 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING KIDNEY DISEASE | ENDOCYTE, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100104626-A1 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING KIDNEY DISEASE | ENDOCYTE, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-7601332-B2 | Minimized toxicity; eliminating pathogenic cell populations; synthesis; claimed intermediates | ENDOCYTE, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601332-B2 | Minimized toxicity; eliminating pathogenic cell populations; synthesis; claimed intermediates | ENDOCYTE, INC. (US) | 2009-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022245-A1 | FOLATE TARGETING OF NUCLEOTIDES | FOLR1, FOLR2, DHFR | AKR1B1 632/4885TYMS 16/4885KDM4E 3509/4885 |
| US-20130144045-A1 | NOVEL SELF-REACTIVE ARMS AND PRODRUGS COMPRISING SAME | CBR3, CBR1, NOX3 | AKR1B1 83/4885TYMS 2414/4885KDM4E 4071/4885 |
| US-20100104626-A1 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING KIDNEY DISEASE | VDR, GC, CYP24A1 | AKR1B1 212/4885TYMS 2951/4885KDM4E 3939/4885 |
| US-20100323973-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | CD44, HAVCR2, HCAR1 | AKR1B1 2255/4885TYMS 2604/4885KDM4E 4752/4885 |
| US-20140073761-A1 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS | CD44, HAVCR2, HCAR1 | AKR1B1 2255/4885TYMS 2604/4885KDM4E 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.