Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.40 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896755 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNABRPF1ALDH1A1DYRK1A | |
| SCHEMBL17896756 | 0.84 | PTGS2 (0.45) | SMN1; SMN2LMNABRPF1ALDH1A1CA12 | |
| SCHEMBL460529 | 0.83 | NAMPT (0.53) | SMN1; SMN2LMNABRPF1ALDH1A1NAMPT | |
| SCHEMBL10176221 | 0.77 | KDM4E (0.52) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL10175462 | 0.75 | KDM4E (0.42) | SMN1; SMN2LMNABRPF1ALDH1A1DYRK1A | |
| SCHEMBL17897056 | 0.73 | MET (0.49) | ALDH1A1POLBNAMPTKITMET | |
| SCHEMBL10175616 | 0.73 | CYP11B1 (0.43) | SMN1; SMN2LMNABRPF1ALDH1A1DYRK1A | |
| SCHEMBL17883783 | 0.73 | CYP11B2 (0.43) | SMN1; SMN2LMNAALDH1A1DYRK1APOLB | |
| SCHEMBL10175468 | 0.71 | MET (0.46) | SMN1; SMN2NAMPTKMT2AKITHDAC1 | |
| SCHEMBL10175617 | 0.69 | CYP11B2 (0.55) | ALDH1A1POLBKMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |