Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loliolide SCHEMBL16057196 | 1.00 | ACHE (0.53) | ACHEPTPN1STAT3HSD11B1 | |
| Loliolide SCHEMBL789415 | 1.00 | ACHE (0.53) | ACHEPTPN1STAT3HSD11B1 | |
| Loliolide SCHEMBL12939655 | 1.00 | ACHE (0.53) | ACHEPTPN1STAT3HSD11B1 | |
| SCHEMBL12848997 | 0.71 | ACHE (0.37) | ACHE | |
| Dihydroactinidiolide SCHEMBL3503557 | 0.69 | ACHE (1.00) | ACHE | |
| D-Dihydroactinidiolide SCHEMBL2186328 | 0.69 | ACHE (1.00) | ACHE | |
| SCHEMBL15507620 | 0.61 | PTPN1 (0.34) | PTPN1 | |
| SCHEMBL31034473 | 0.60 | PTPN1 (0.46) | PTPN1 | |
| SCHEMBL23059477 | 0.57 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL6664619 | 0.57 | ACHE (0.43) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-28 | — | — | US | disclosed |
| WO-2012037069-A2 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | WEE1, WEE2, NOTUM | ACHE 3674/4885PTPN1 4764/4885STAT3 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.