Loliolide

Loliolide

SCHEMBL789415

CC1(C)C[C@H](O)C[C@@]2(C)OC(=O)C=C12

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 1/20 0.53
▸ PTPN1 P18031 1/20 0.32
▸ STAT3 P40763 1/20 0.31
▸ HSD11B1 P28845 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Loliolide SCHEMBL16057196 1.00 ACHE (0.53) ACHEPTPN1STAT3HSD11B1
Loliolide SCHEMBL10181773 1.00 ACHE (0.53) ACHEPTPN1STAT3HSD11B1
Loliolide SCHEMBL12939655 1.00 ACHE (0.53) ACHEPTPN1STAT3HSD11B1
SCHEMBL12848997 0.71 ACHE (0.37) ACHE
Dihydroactinidiolide SCHEMBL3503557 0.69 ACHE (1.00) ACHE
D-Dihydroactinidiolide SCHEMBL2186328 0.69 ACHE (1.00) ACHE
SCHEMBL15507620 0.61 PTPN1 (0.34) PTPN1
SCHEMBL31034473 0.60 PTPN1 (0.46) PTPN1
SCHEMBL23059477 0.57 HSD11B1 (0.37) HSD11B1
SCHEMBL6664619 0.57 ACHE (0.43) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070853-A1 PROCESS FOR PRODUCING BIOFERTILIZERS/BIOSTIMULANTS FROM MICROALGAE OF THE SPECIES SCENEDESMUS SP. WITH INTENSIVE CO2 CAPTURE, BIOFERTILIZERS/BIOSTIMULANTS OBTAINED BY SAID PROCESS AND THEIR USES IN AGRICULTURE Petróleo Brasileiro S.A. - Petrobras (BR) 2026-03-12 — — US claimed
US-12329850-B2 Microalgae having high loliolide productivity KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2025-06-17 — — US claimed
CN-116375669-B Monoterpene lactone compound, preparation method thereof and application thereof in preparation of anticomplement medicines 复旦大学 2025-05-16 — — CN claimed
US-20230390355-A1 COMPOSITIONS AND METHODS RELATING TO ALOPECIA ALASTIN Skincare, Inc. (US) 2023-12-07 — — US claimed
CN-116407533-A Application of sesquiterpenoids lolide in preparing medicament for treating viral pneumonia 复旦大学 2023-07-11 — — CN claimed
US-20220387295-A1 NOVEL MICROALGAE HAVING HIGH LOLIOLIDE PRODUCTIVITY KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2022-12-08 — — US claimed
CN-105439998-B A kind of method that loliolide is separated in the knurl ascidian from wrinkle 厦门医学院 2017-08-04 — — CN claimed
US-20170014463-A1 Composition Comprising Plants Extracts that Synergistically Treat or Inhibit Pathological Conditions and Method of Making NOLAN BRUCE (US) 2017-01-19 — — US claimed
US-20160137663-A1 NOVEL SESQUITERPENOID STAT3 INHIBITORS UNIVERSITY OF HAWAII (US) 2016-05-19 — — US claimed
CN-105439998-A Method for separating lolium lactone from styela plicata XIAMEN MEDICAL COLLEGE 2016-03-30 — — CN claimed
US-20160051604-A1 SEAWEED EXTRACTS, UNSATURATED ALDEHYDES, AND METHODS OF TREATMENT UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2016-02-25 — — US claimed
WO-2014205416-A1 NOVEL SESQUITERPENOID STAT3 INHIBITORS UNIVERSITY OF HAWAII (US) 2014-12-24 — — WO claimed
WO-2014144765-A1 SEAWEED EXTRACTS, UNSATURATED ALDEHYDES, AND METHODS OF TREATMENT UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) 2014-09-18 — — WO claimed
WO-2014038872-A1 COMPOSITION FOR INHIBITING CELLULAR SENESCENCE COMPRISING LOLIOLIDE INDUSTRY-ACADEMIC COOPERATION FOUNDATION,YEUNGNAM UNIVERSITY (KR) 2014-03-13 — — WO claimed
CN-102827119-A Method for extracting and purifying ryegrass lactone NANJING ZELANG MEDICAL TECH CO 2012-12-19 — — CN claimed
WO-2011144639-A1 EXTRACT OF PARTS OF SAMBUCUS FOR USE IN THE TREATMENT OF INFLAMMATORY PROCESSES, INTIMAL HYPERPLASIA AND VEIN GRAFT DISEASE BIONORICA SE (DE) 2011-11-24 — — WO claimed
US-20100125102-A1 ESTROGENIC-ACTIVE COMPOUNDS AND APPLICATION THEREOF NATIONAL TAIWAN UNIVERSITY (TW) 2010-05-20 — — US claimed
JP-7138156-A — — None — — JP disclosed
US-5081310-A PROCESS FOR PREPARING OPTICALLY ACTIVE KETONES TAKASAGO INTERNATIONAL CORPORATION (JP) 1992-01-14 — — US disclosed
EP-0409530-A1 Catalytic preparation of optically active ketones Takasago International Corporation (JP) 1991-01-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070853-A1 PROCESS FOR PRODUCING BIOFERTILIZERS/BIOSTIMULANTS FROM MICROALGAE OF THE SPECIES SCENEDESMUS SP. WITH INTENSIVE CO2 CAPTURE, BIOFERTILIZERS/BIOSTIMULANTS OBTAINED BY SAID PROCESS AND THEIR USES IN AGRICULTURE CCNB2, CCNB3, CHRM2 ACHE 1245/4885PTPN1 4324/4885STAT3 2704/4885
US-20160051604-A1 SEAWEED EXTRACTS, UNSATURATED ALDEHYDES, AND METHODS OF TREATMENT KEAP1, NFE2L2, ALOX15 ACHE 691/4885PTPN1 4847/4885STAT3 51/4885
US-20160137663-A1 NOVEL SESQUITERPENOID STAT3 INHIBITORS STAT3, JAK2, STAT6 ACHE 4885/4885PTPN1 261/4885STAT3 1/4885
US-20100125102-A1 ESTROGENIC-ACTIVE COMPOUNDS AND APPLICATION THEREOF ESR1, ESR2, GPER1 ACHE 896/4885PTPN1 1388/4885STAT3 832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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