Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 13/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186664 | 0.94 | MEN1 (0.55) | MEN1KMT2ATP53CYP3A4CYP2D6 | |
| SCHEMBL661726 | 0.86 | MEN1 (0.46) | MEN1KMT2ATP53CYP3A4CYP2D6 | |
| SCHEMBL10186685 | 0.81 | HTR1A (0.42) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10186681 | 0.81 | POLB (0.45) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL664699 | 0.80 | MEN1 (0.51) | MEN1KMT2ATP53CYP3A4CYP2D6 | |
| SCHEMBL10186620 | 0.77 | POLB (0.41) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10186666 | 0.75 | SLC6A4 (0.51) | SIGMAR1 | |
| SCHEMBL10186676 | 0.74 | LMNA (0.39) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL10186682 | 0.73 | SIGMAR1 (0.36) | MEN1KMT2ACYP3A4CYP2C19SIGMAR1 | |
| SCHEMBL3093517 | 0.72 | PRMT5 (0.55) | MEN1KMT2ATP53CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MEN1 3395/4885KMT2A 4587/4885TP53 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.