Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 6/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776861 | 0.83 | ALDH1A1 (0.45) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20244667 | 0.81 | ALDH1A1 (0.53) | LMNAALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL6541372 | 0.81 | CA2 (0.47) | LMNAALDH1A1 | |
| SCHEMBL10187470 | 0.80 | LMNA (0.58) | LMNAPLA2G10PLA2G2AALDH1A1CALM1 | |
| SCHEMBL8164406 | 0.80 | ALDH1A1 (0.44) | LMNAALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL31260342 | 0.79 | HRH3 (0.47) | ALDH1A1RAB9AMEN1KMT2ASLC6A2 | |
| SCHEMBL2578840 | 0.79 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL5574240 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1602482 | 0.77 | PLA2G10 (0.41) | LMNAPLA2G10PLA2G2AALDH1A1LTA4H | |
| SCHEMBL28861673 | 0.77 | HPGD (0.55) | LMNAALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093287-B2 | Inhibitors of matrix metalloproteinases | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110293643-A1 | COMPOUNDS AND METHODS FOR INHIBITING MMP2 AND MMP9 | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2011-12-01 | — | — | US | disclosed |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | NOTRE DAME UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110293643-A1 | COMPOUNDS AND METHODS FOR INHIBITING MMP2 AND MMP9 | MMP9, MMP26, MMP2 | LMNA 3053/4885PLA2G10 1452/4885PLA2G2A 1179/4885 |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | MMP9, MMP1, MMP2 | LMNA 358/4885PLA2G10 744/4885PLA2G2A 1407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.