Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.54 |
| ▸ | PPARA | Q07869 | 8/20 | 0.54 |
| ▸ | LTA4H | P09960 | 3/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | BAX | Q07812 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906889 | 0.93 | PPARG (0.44) | PPARGPPARALTA4HFFAR1PPARD | |
| SCHEMBL2940745 | 0.82 | TRPA1 (0.48) | — | |
| SCHEMBL10577323 | 0.82 | TRPA1 (0.48) | — | |
| SCHEMBL1552843 | 0.81 | PPARG (0.58) | PPARGPPARALTA4HFFAR1PPARD | |
| SCHEMBL1552840 | 0.81 | PPARG (0.58) | PPARGPPARALTA4HFFAR1PPARD | |
| SCHEMBL28633253 | 0.79 | SRR (0.50) | PPARGPPARAFFAR1MMP12MMP13 | |
| SCHEMBL10187479 | 0.79 | SRR (0.50) | PPARGPPARAFFAR1MMP12MMP13 | |
| SCHEMBL15517655 | 0.79 | SRR (0.50) | PPARGPPARAFFAR1MMP12MMP13 | |
| SCHEMBL11823926 | 0.79 | MMP12 (0.67) | PPARGPPARALTA4HFFAR1PPARD | |
| SCHEMBL11446097 | 0.79 | LTA4H (0.48) | PPARGPPARALTA4HFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093287-B2 | Inhibitors of matrix metalloproteinases | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | NOTRE DAME UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
| US-7928127-B2 | Inhibitors of matrix metallaproteinases | NOTRE DAME UNIVERSITY (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-01 | — | — | US | disclosed |
| US-3966801-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005420-A1 | Inhibitors of Matrix Metallaproteinases | MMP9, MMP1, MMP2 | PPARG 4192/4885PPARA 4460/4885LTA4H 504/4885 |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | MMP9, MMP1, MMP2 | PPARG 4218/4885PPARA 4621/4885LTA4H 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.