Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | CFB | P00751 | 5/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10188888 | 0.81 | PKN1 (0.51) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021674 | 0.81 | METAP2 (0.46) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11018070 | 0.79 | METAP2 (0.44) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11022217 | 0.79 | ATR (0.53) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021091 | 0.78 | ATR (0.48) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11018831 | 0.78 | TOP1 (0.46) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021240 | 0.77 | MAPT (0.46) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL11021741 | 0.77 | ATR (0.44) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL14514686 | 0.76 | RHEB (0.57) | METAP2METAP1PKN1PKN2CHEK2 | |
| Hydrochloric Acid SCHEMBL5647675 | 0.76 | RHEB (0.56) | METAP2METAP1PKN1PKN2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |