Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 5/20 | 0.46 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6370737 | 0.88 | HTR1A (0.49) | CCR5HTR1ADRD2ALDH1A1RAB9A | |
| SCHEMBL1023923 | 0.84 | ELANE (0.53) | CCR5HTR1ADRD2APPUSP28 | |
| SCHEMBL6213896 | 0.84 | CCR5 (0.49) | CCR5HTR1ADRD2APPFFAR1 | |
| SCHEMBL561347 | 0.82 | CCR5 (0.68) | CCR5ALDH1A1RAB9AUSP28USP25 | |
| SCHEMBL28330023 | 0.82 | ALOX5 (0.54) | CCR5HTR1ADRD2ALDH1A1RAB9A | |
| SCHEMBL30353418 | 0.82 | CCR5 (0.68) | CCR5ALDH1A1RAB9AUSP28USP25 | |
| SCHEMBL31375355 | 0.81 | APP (0.56) | HTR1ADRD2RAB9AAPPFFAR1 | |
| SCHEMBL11647126 | 0.81 | APP (0.56) | HTR1ADRD2RAB9AAPPFFAR1 | |
| SCHEMBL15583063 | 0.81 | HTR1A (0.51) | CCR5HTR1ADRD2ALDH1A1RAB9A | |
| SCHEMBL562155 | 0.81 | PTGER1 (0.55) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797110-B1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO KG (DE) | 2011-01-12 | — | — | EP | disclosed |
| US-7446102-B2 | Antibacterial amide macrocycles IV | AICURIS GMBH & CO. KG (DE) | 2008-11-04 | — | — | US | disclosed |
| US-7446102-B2 | Antibacterial amide macrocycles IV | AICURIS GMBH & CO. KG (DE) | 2008-11-04 | — | — | US | disclosed |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO. KG (DE) | 2008-03-27 | — | — | US | disclosed |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO. KG (DE) | 2008-03-27 | — | — | US | disclosed |
| EP-1797110-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AiCuris GmbH & Co. KG (DE) | 2007-06-20 | — | — | EP | disclosed |
| US-20070129288-A1 | Antibacterial amide macrocycles | BAYER HEALTHCARE AG (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070129288-A1 | Antibacterial amide macrocycles | BAYER HEALTHCARE AG (DE) | 2007-06-07 | — | — | US | disclosed |
| EP-1515983-B1 | ANTIBACTERIAL AMIDE MACROCYCLES | AICURIS GMBH & CO KG (DE) | 2007-02-21 | — | — | EP | disclosed |
| US-20060258571-A1 | Antibacterial ester macrocycles | AICURIS GMBH & CO. KG (DE) | 2006-11-16 | — | — | US | disclosed |
| WO-2006034786-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO.KG (DE) | 2006-04-06 | — | — | WO | disclosed |
| US-20050256037-A1 | Antibacterial amide macrocyles | BAYER HEALTHCARE AG (DE) | 2005-11-17 | — | — | US | disclosed |
| EP-1526896-A1 | ANTIBACTERIAL ESTER MACROCYCLES | Bayer HealthCare AG (DE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2005033129-A1 | ANTIBACTERIAL AMIDE MACROCYCLES | BAYER HEALTHCARE AG (DE) | 2005-04-14 | — | — | WO | disclosed |
| EP-1515983-A1 | ANTIBACTERIAL AMIDE MACROCYCLES | Bayer HealthCare AG (DE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004012816-A1 | ANTIBACTERIAL ESTER MACROCYCLES | BAYER HEALTHCARE AG (DE) | 2004-02-12 | — | — | WO | disclosed |
| WO-2003106480-A1 | ANTIBACTERIAL AMIDE MACROCYCLES | BAYER HEALTHCARE AG (DE) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129288-A1 | Antibacterial amide macrocycles | AADAC, AAAS, MRPL21 | CCR5 2064/4885HTR1A 4376/4885DRD2 3299/4885 |
| US-20080076745-A1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | NOD2, AAAS, AADAC | CCR5 2756/4885HTR1A 4729/4885DRD2 3742/4885 |
| US-20050256037-A1 | Antibacterial amide macrocyles | AADAC, PAM, NOD2 | CCR5 3965/4885HTR1A 4576/4885DRD2 3865/4885 |
| US-20060258571-A1 | Antibacterial ester macrocycles | TECR, MRPL21, CYP51A1 | CCR5 1796/4885HTR1A 4802/4885DRD2 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.