Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145600 | 1.00 | IDO1 (0.40) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL11566406 | 0.76 | ALDH1A1 (0.35) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL1629226 | 0.76 | ALDH1A1 (0.47) | IDO1TDO2CCR1ALDH1A1TDP1 | |
| SCHEMBL4910575 | 0.76 | IDO1 (0.37) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL10907202 | 0.74 | PARP10 (0.39) | MAPT | |
| SCHEMBL3495437 | 0.74 | TSHR (0.50) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL2339911 | 0.74 | ALDH1A1 (0.38) | IDO1TDO2CES2CES1ALDH1A1 | |
| SCHEMBL7868609 | 0.74 | IDO1 (0.40) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL27782003 | 0.74 | TRPA1 (0.50) | IDO1TDO2CES2CES1CCR1 | |
| SCHEMBL2163400 | 0.74 | TSHR (0.50) | IDO1TDO2CES2CES1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253404-B | Nitrogen-containing heterocyclic compound and composition, preparation method and application thereof | 上海医药集团股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-20220048915-A1 | Nitrogen-containing Heterocyclic Compound and Composition Thereof, Preparation Method Therefor, and Application Thereof | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2022-02-17 | — | — | US | disclosed |
| EP-3889156-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| CN-106795117-A | Heterobicyclic compounds and their use for the treatment of tuberculosis | 大塚制药株式会社 | 2017-05-31 | — | — | CN | disclosed |
| CN-102159207-B | Substituted pyrrolidine-2-carboxamides | HOFFMANN LA ROCHE | 2015-02-04 | — | — | CN | disclosed |
| US-20140288074-A1 | FUNGICIDAL PYRAZOLES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-09-25 | — | — | US | disclosed |
| US-8541406-B2 | Thiadiazole derivatives for the treatment of neurodegenerative diseases | NV REMYND (BE) | 2013-09-24 | — | — | US | disclosed |
| US-7960556-B2 | Thiadiazole derivatives for the treatment of neuro-degenerative diseases | NV REMYND (BE) | 2011-06-14 | — | — | US | disclosed |
| EP-2094677-B1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | REMYND NV (BE) | 2011-01-12 | — | — | EP | disclosed |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2010-10-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| EP-0382588-B1 | METHOD FOR THE REDUCTION OF A REFINING CATALYST BEFORE ITS USE | EURECAT EUROPEENNE DE RETRAITEMENT DE CATALYSEURS (FR) | 1993-03-24 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |
| EP-0251775-B1 | ALPHA-ARYL-ALPHA-PHENYLETHYL-1H-1,2,4-TRIAZOLE-1-PROPANENITRILES | ROHM AND HAAS COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0349358-B1 | PROCESS FOR PRESULFIDING AND CONTROLLING THE ACTIVITY OF A HYDROCARBON TREATMENT CATALYST | EURECAT EUROPEENNE DE RETRAITEMENT DE CATALYSEURS (FR) | 1992-03-04 | — | — | EP | disclosed |
| US-5087635-A | Funcicides | ROHM AND HAAS COMPANY (US) | 1992-02-11 | — | — | US | disclosed |
| US-5059731-A | Selectively hydrogenating acetylenic and diolefinic hydrocarbons | EUROPEANE DE RETRAITEMENT DE CATALYSEURS EURECAT (FR) | 1991-10-22 | — | — | US | disclosed |
| US-4983559-A | CATALYTIC REGENERATION | EUROPEENE DE RETRAITEMENT DE CATALYSEURS EURECAT (FR) | 1991-01-08 | — | — | US | disclosed |
| EP-0349358-A1 | Process for presulfiding and controlling the activity of a hydrocarbon treatment catalyst | EURECAT EUROPEENNE DE RETRAITEMENT DE CATALYSEURS (FR) | 1990-01-03 | — | — | EP | disclosed |
| EP-0251775-A2 | Alpha-aryl-alpha-phenylethyl-1H-1,2,4-triazole-1-propanenitriles | ROHM AND HAAS COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | IDO1 1637/4885TDO2 1902/4885CES2 3923/4885 |
| US-20220048915-A1 | Nitrogen-containing Heterocyclic Compound and Composition Thereof, Preparation Method Therefor, and Application Thereof | MAPK11, WEE1, NOS1 | IDO1 1135/4885TDO2 2337/4885CES2 4408/4885 |
| US-20140288074-A1 | FUNGICIDAL PYRAZOLES | CYP1A1, CYP1B1, NOX3 | IDO1 181/4885TDO2 317/4885CES2 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.