SCHEMBL10243492

SCHEMBL10243492

CC(C)(C)c1cnc2cccnc2c1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OGA O60502 2/20 0.41
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
PABPC1 P11940 1/20 0.39
EIF4H Q15056 1/20 0.39
ALDH1A1 P00352 4/20 0.39
KIF11 P52732 1/20 0.38
KDM4E B2RXH2 3/20 0.38
TRPV1 Q8NER1 2/20 0.37
KDR P35968 1/20 0.37
PDE10A Q9Y233 1/20 0.36
MAPT P10636 1/20 0.35
ATAD2 Q6PL18 1/20 0.35
METAP2 P50579 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12524759 0.82 OGA (0.38) OGAALDH1A1PDE10A
SCHEMBL25597712 0.81 OGA (0.38) OGAKMT2AALDH1A1KDM4EPDE10A
SCHEMBL24656108 0.80 PDE10A (0.36) OGAKMT2AMEN1KDM4ETRPV1
SCHEMBL25515395 0.80 GNRHR (0.35) ALDH1A1KDM4EPDE10AMAPTMETAP2
SCHEMBL24176501 0.77 OGA (0.41) OGAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL26795804 0.76 KIF11 (0.31) KIF11TRPV1PDE10A
SCHEMBL761268 0.75 ALDH1A1 (0.42) KMT2AMEN1ALDH1A1KIF11KDM4E
SCHEMBL418110 0.74 CYP1A2 (0.57) ALDH1A1KDM4ETRPV1MAPT
SCHEMBL21900465 0.74 CYP1A2 (0.41) KMT2AMEN1ALDH1A1
SCHEMBL130023 0.74 CYP1A2 (0.55) ALDH1A1KDM4EMAPTATAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858945-B2 Alkyne-containing antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-01-02 US disclosed
US-20230382909-A1 BICYCLIC COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-11-30 US disclosed
US-20230374008-A1 BICYCLIC COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-11-23 US disclosed
US-20230374008-A1 BICYCLIC COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-11-23 US disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20230242531-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-08-03 US disclosed
US-20230242531-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-08-03 US disclosed
US-20230174531-A1 SATURATED SPIROCYCLICS AS ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2023-06-08 US disclosed
US-20230159545-A1 ALKYNE-CONTAINING ANTIVIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2023-05-25 US disclosed
US-8846928-B2 Benzamides and nicotinamides as Syk modulators PORTOLA PHARMACEUTICALS, INC. (US) 2014-09-30 US disclosed
US-20140038948-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2014-02-06 US disclosed
US-20130237531-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. 2013-09-12 US disclosed
US-20120238751-A1 TRICYCLIC GYRASE INHIBITORS TRIUS THERAPEUTICS, INC. (US) 2012-09-20 US disclosed
US-20120142671-A1 BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS PORTOLA PHARMACEUTICALS, INC. (US) 2012-06-07 US disclosed
US-8097708-B2 10a-Azalide compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-01-17 US disclosed
US-20100190777-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2010-07-29 US disclosed
US-20090281292-A1 10a-Azalide Compound MEIJI SEIKA PHARMA CO., LTD. (JP) 2009-11-12 US disclosed
US-7332476-B2 Pyridyl substituted ketolide antibiotics NOVARTIS AG (CH) 2008-02-19 US disclosed
US-7332476-B2 Pyridyl substituted ketolide antibiotics NOVARTIS AG (CH) 2008-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242531-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP OGA 2708/4885KMT2A 2234/4885MEN1 4127/4885
US-20120238751-A1 TRICYCLIC GYRASE INHIBITORS TOP1, TOP2A, TOP2B OGA 1096/4885KMT2A 3095/4885MEN1 3398/4885
US-20120142671-A1 BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS SYK, BTK, NADK OGA 2491/4885KMT2A 1192/4885MEN1 3407/4885
US-20130237531-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, MAP3K13, MAP3K8 OGA 2024/4885KMT2A 1133/4885MEN1 1452/4885
US-20230382909-A1 BICYCLIC COMPOUNDS SLC10A1, PKD1, CYP11B2 OGA 2657/4885KMT2A 3870/4885MEN1 262/4885
US-20100190777-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, MAP3K11, MAP3K10 OGA 2914/4885KMT2A 959/4885MEN1 1529/4885
US-20230374008-A1 BICYCLIC COMPOUNDS SLC10A1, PKD1, CYP11B2 OGA 2657/4885KMT2A 3870/4885MEN1 262/4885
US-11858945-B2 Alkyne-containing antiviral agents ACE, SARS1, ACE2 OGA 2859/4885KMT2A 3482/4885MEN1 4315/4885
US-20230174531-A1 SATURATED SPIROCYCLICS AS ANTIVIRAL AGENTS ACE, ACE2, PKD1 OGA 3554/4885KMT2A 4141/4885MEN1 3626/4885
US-20140038948-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, MAP3K13, MAP3K8 OGA 2024/4885KMT2A 1133/4885MEN1 1452/4885
US-20090281292-A1 10a-Azalide Compound IL17A, AZI2, HDAC9 OGA 4647/4885KMT2A 939/4885MEN1 2456/4885
US-20230159545-A1 ALKYNE-CONTAINING ANTIVIRAL AGENTS ACE, SARS1, ACE2 OGA 2859/4885KMT2A 3482/4885MEN1 4315/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP OGA 1753/4885KMT2A 1069/4885MEN1 4128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.