Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028658 | 0.88 | EGLN1 (0.46) | EGLN1FTOBBOX1KDM4EHPGD | |
| SCHEMBL1033035 | 0.86 | EGLN1 (0.47) | EGLN1FTOBBOX1KDM4ESMN1; SMN2 | |
| SCHEMBL1033539 | 0.85 | EGLN1 (0.46) | EGLN1FTOBBOX1TSHR | |
| SCHEMBL1032271 | 0.84 | FTO (0.43) | EGLN1FTOBBOX1 | |
| SCHEMBL1031021 | 0.82 | NPC1 (0.38) | EGLN1KDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1033585 | 0.82 | THRA (0.41) | EGLN1KDM4ESMN1; SMN2HPGDTP53 | |
| SCHEMBL523025 | 0.81 | EGLN1 (0.67) | EGLN1FTOBBOX1KDM4ESMN1; SMN2 | |
| SCHEMBL4081511 | 0.79 | EGLN1 (0.49) | EGLN1FTOBBOX1KDM4EHPGD | |
| SCHEMBL1033387 | 0.75 | FTO (0.46) | EGLN1FTOBBOX1KDM4ETP53 | |
| SCHEMBL4070933 | 0.74 | SMN1; SMN2 (0.43) | EGLN1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN INC (US) | 2011-01-19 | — | — | EP | claimed |