Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033035 | 0.88 | EGLN1 (0.47) | EGLN1FTOBBOX1ALDH1A1KDM4E | |
| SCHEMBL1028622 | 0.88 | EGLN1 (0.47) | EGLN1FTOBBOX1ALDH1A1KDM4E | |
| SCHEMBL1033539 | 0.87 | EGLN1 (0.46) | EGLN1FTOBBOX1CYP1A2TSHR | |
| SCHEMBL1032271 | 0.86 | FTO (0.43) | EGLN1FTOBBOX1 | |
| SCHEMBL4081511 | 0.81 | EGLN1 (0.49) | EGLN1FTOBBOX1ALDH1A1KDM4E | |
| SCHEMBL522620 | 0.79 | EGLN1 (0.69) | EGLN1FTOBBOX1 | |
| SCHEMBL1033387 | 0.77 | FTO (0.46) | EGLN1FTOBBOX1KDM4ETP53 | |
| SCHEMBL4073465 | 0.76 | EGLN1 (0.49) | EGLN1FTOBBOX1ALDH1A1KDM4E | |
| SCHEMBL4070933 | 0.74 | SMN1; SMN2 (0.43) | EGLN1HPGDHSD17B10MTNR1AMTNR1B | |
| SCHEMBL4074699 | 0.74 | SMN1; SMN2 (0.43) | EGLN1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN INC (US) | 2011-01-19 | — | — | EP | claimed |