Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 8/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 4/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837024 | 0.87 | GLP1R (0.42) | GLP1RSIRT1SIRT2TLR2SIRT6 | |
| SCHEMBL12695715 | 0.85 | GLP1R (0.39) | GLP1RSIRT1TLR2SIRT6TGM2 | |
| SCHEMBL2607889 | 0.83 | SIRT2 (0.45) | SIRT1SIRT2SIRT6TGM2HDAC4 | |
| SCHEMBL836829 | 0.83 | ACHE (0.44) | — | |
| SCHEMBL2607891 | 0.82 | SIRT1 (0.44) | SIRT1SIRT2SIRT6HDAC4EP300 | |
| SCHEMBL12410205 | 0.81 | SIRT1 (0.49) | SIRT1SIRT2SIRT6HDAC4EP300 | |
| SCHEMBL13749785 | 0.81 | SIRT6 (0.48) | GLP1RSIRT1TLR2SIRT6 | |
| SCHEMBL13311516 | 0.81 | SIRT2 (0.45) | SIRT1SIRT2SIRT6HDAC4EP300 | |
| SCHEMBL17486501 | 0.80 | EPHX2 (0.39) | SIRT1SIRT2TGM2HDAC4EP300 | |
| SCHEMBL12583936 | 0.79 | SIRT1 (0.47) | SIRT1SIRT2SIRT6HDAC4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9446139-B2 | Polymer-based compositions and conjugates of HIV entry inhibitors | NEKTAR THERAPEUTICS (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160175402-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2016-06-23 | — | — | US | disclosed |
| US-8889831-B2 | Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate | NEKTAR THERAPEUTICS (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120178692-A1 | DOSAGE FORMS OF POLYMER-FACTOR VIII MOIETY CONJUGATES | NEKTAR THERAPEUTICS (US) | 2012-07-12 | — | — | US | disclosed |
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | NEKTAR THERAPEUTICS (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171166-A1 | POLYMER CONJUGATES OF OSTEOCALCIN PEPTIDES | NEKTAR THERAPEUTICS | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | KISS1R, PROKR1, NGLY1 | GLP1R 13/4885SIRT1 473/4885SIRT2 1016/4885 |
| US-20160175402-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | F8, F9, F13B | GLP1R 4739/4885SIRT1 4382/4885SIRT2 4157/4885 |
| US-20120178692-A1 | DOSAGE FORMS OF POLYMER-FACTOR VIII MOIETY CONJUGATES | F8, F9, F13B | GLP1R 4662/4885SIRT1 4220/4885SIRT2 4051/4885 |
| US-20110171166-A1 | POLYMER CONJUGATES OF OSTEOCALCIN PEPTIDES | SOST, PTMS, ALPP | GLP1R 354/4885SIRT1 1581/4885SIRT2 2572/4885 |
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | GAA, MAN2B1, GBA1 | GLP1R 2600/4885SIRT1 3115/4885SIRT2 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.