Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029042 | 0.88 | LMNA (0.44) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1028175 | 0.86 | TP53 (0.52) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1032620 | 0.80 | HTT (0.53) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1034078 | 0.79 | MAPT (0.46) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1031214 | 0.79 | KCNH2 (0.46) | LMNAALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL1029484 | 0.78 | HSD11B1 (0.47) | ALDH1A1PKML3MBTL1 | |
| SCHEMBL1030249 | 0.78 | ALDH1A1 (0.46) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL1031811 | 0.78 | HPGD (0.54) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1030828 | 0.76 | MAPT (0.47) | LMNAMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1032634 | 0.74 | ALDH1A1 (0.41) | LMNAALDH1A1SMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |