Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030369 | 0.87 | MAPT (0.43) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1028175 | 0.80 | TP53 (0.52) | MAPTMEN1KMT2ACNR2SLC6A7 | |
| SCHEMBL1033202 | 0.77 | KCNA5 (0.46) | KDM4EMEN1KMT2AL3MBTL1TP53 | |
| SCHEMBL1028655 | 0.74 | KCNA5 (0.44) | KDM4EMEN1KMT2AL3MBTL1TP53 | |
| SCHEMBL1032620 | 0.74 | HTT (0.53) | MAPTMEN1KMT2ACNR2TP53 | |
| SCHEMBL13150673 | 0.73 | CASP1 (0.52) | MAPTKDM4EL3MBTL1ALDH1A1POLB | |
| SCHEMBL1029484 | 0.72 | HSD11B1 (0.47) | L3MBTL1ALDH1A1 | |
| SCHEMBL1031902 | 0.72 | LMNA (0.45) | MAPTKDM4EL3MBTL1TP53ALDH1A1 | |
| SCHEMBL1031811 | 0.72 | HPGD (0.54) | MAPTKDM4EMEN1KMT2ACNR2 | |
| SCHEMBL1031214 | 0.71 | KCNH2 (0.46) | KDM4EMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |