Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590907 | 0.82 | PGR (0.58) | PGRBRD4HSD17B2PTPN2PTPN1 | |
| SCHEMBL10328504 | 0.82 | PGR (0.48) | PGRPTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL13667269 | 0.81 | RORC (0.52) | BRD4PTGDR2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10328527 | 0.77 | LMNA (0.53) | PTPN2PTPN1PTPN5KDM4EMEN1 | |
| SCHEMBL10328531 | 0.76 | KEAP1 (0.47) | PGRMAP2K4MEN1ALDH1A1LMNA | |
| SCHEMBL10328535 | 0.76 | AXL (0.45) | PGRHSD17B2MEN1LMNAGAA | |
| SCHEMBL10328514 | 0.75 | ACLY (0.45) | PGRPTPN2PTPN1PTPN5MAP2K4 | |
| SCHEMBL1489068 | 0.74 | PGR (0.65) | PGRBRD4HSD17B2PTPN2PTPN1 | |
| SCHEMBL10328517 | 0.74 | ACLY (0.44) | MEN1ALDH1A1LMNAGLAKMT2A | |
| SCHEMBL10328534 | 0.72 | AGTR1 (0.44) | PTGDR2MEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |
| WO-2009127417-A1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-10-22 | — | — | WO | disclosed |