Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 8/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 6/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 6/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591669 | 0.82 | SMN1; SMN2 (0.47) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13667269 | 0.81 | RORC (0.52) | ALDH1A1HPGDHTTKITSMN1; SMN2 | |
| SCHEMBL10328504 | 0.78 | PGR (0.48) | MAPTALDH1A1HTTPTPN1PTPN2 | |
| SCHEMBL10328517 | 0.78 | ACLY (0.44) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL10328523 | 0.77 | PGR (0.47) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7573917 | 0.73 | MAPT (0.64) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10328495 | 0.72 | TP53 (0.43) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10328534 | 0.70 | AGTR1 (0.44) | LMNAMAPTMEN1KMT2AHTT | |
| SCHEMBL19334352 | 0.69 | LMNA (0.67) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13059432 | 0.66 | KDM4E (0.47) | ALDH1A1HTTSMN1; SMN2CASP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |
| WO-2009127417-A1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-10-22 | — | — | WO | disclosed |