Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12526907 | 1.00 | OPRK1 (0.37) | OPRK1MIFHSP90AA1HSP90AB1NPC1 | |
| SCHEMBL10330713 | 0.96 | HSP90AA1 (0.37) | OPRK1MIFHSP90AA1HSP90AB1NPC1 | |
| SCHEMBL12526863 | 0.89 | PDK2 (0.34) | NPC1RAB9ASMN1; SMN2APPKDM4E | |
| SCHEMBL15923274 | 0.86 | SLC22A12 (0.37) | OPRK1MIFKDM4ETDP1CHEK1 | |
| SCHEMBL16975985 | 0.86 | OPRK1 (0.36) | OPRK1MIFHSP90AA1HSP90AB1APP | |
| Sp-420 SCHEMBL1314906 | 0.86 | SLC22A12 (0.37) | OPRK1MIFKDM4ETDP1CHEK1 | |
| SCHEMBL12852164 | 0.86 | OPRK1 (0.36) | OPRK1MIFHSP90AA1HSP90AB1APP | |
| SCHEMBL11963323 | 0.86 | SLC22A12 (0.37) | OPRK1MIFKDM4ETDP1CHEK1 | |
| SCHEMBL18499305 | 0.86 | OPRK1 (0.36) | OPRK1MIFHSP90AA1HSP90AB1APP | |
| SCHEMBL1315301 | 0.86 | SLC22A12 (0.37) | OPRK1MIFKDM4ETDP1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170209420-A1 | USES OF 4'-DESFERRITHIOCIN ANALOGS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20140343110-A1 | USES OF 4'-DESFERRITHIOCIN ANALOGS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-11-20 | — | — | US | disclosed |
| US-20120184586-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| US-20110275636-A1 | DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | FERROKIN BIOSCIENCES, INC. (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275636-A1 | DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS | SLC39A14, SLC40A1, FTH1 | OPRK1 2173/4885MIF 3549/4885HSP90AA1 1429/4885 |
| US-20120184586-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES AND USES THEREOF | TFRC, FTH1, TTPA | OPRK1 2243/4885MIF 3238/4885HSP90AA1 1214/4885 |
| US-20140343110-A1 | USES OF 4'-DESFERRITHIOCIN ANALOGS | TFRC, AIFM2, VIP | OPRK1 792/4885MIF 444/4885HSP90AA1 2827/4885 |
| US-20170209420-A1 | USES OF 4'-DESFERRITHIOCIN ANALOGS | TFRC, AIFM2, VIP | OPRK1 792/4885MIF 444/4885HSP90AA1 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.