Sugi Predict

Sugi Predict / Compounds / SCHEMBL10338995

SCHEMBL10338995

SCHEMBL10338995

O=C(O)c1nsnc1-c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.52
▸ LMNA P02545 2/20 0.52
▸ RAB9A P51151 2/20 0.45
▸ THRB P10828 1/20 0.45
▸ ALDH1A1 P00352 4/20 0.43
▸ HPGD P15428 2/20 0.43
▸ TSHR P16473 1/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ MAPT P10636 1/20 0.42
▸ TP53 P04637 1/20 0.42
▸ PIN1 Q13526 2/20 0.41
▸ NR4A2 P43354 1/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ CASP1 P29466 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ PTPN1 P18031 1/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ CDC7 O00311 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14582775 0.85 THRB (0.63) KDM4ELMNARAB9ATHRBALDH1A1
SCHEMBL8400102 0.83 CA12 (0.46) KDM4ERAB9AALDH1A1HPGDMAPT
SCHEMBL8396813 0.83 ALPL (0.46) KDM4ELMNARAB9AALDH1A1HPGD
SCHEMBL8519653 0.83 CA12 (0.46) KDM4ELMNARAB9AALDH1A1HPGD
SCHEMBL8400170 0.81 PIN1 (0.51) RAB9ATHRBTSHRMAPTPIN1
SCHEMBL8396801 0.81 PIN1 (0.49) RAB9APIN1PTPN1NPC1
SCHEMBL8397343 0.81 PIN1 (0.50) KDM4ESMN1; SMN2PIN1NR4A2
SCHEMBL20028494 0.80 SMN1; SMN2 (0.58) KDM4ELMNARAB9AALDH1A1HPGD
SCHEMBL8400437 0.79 ALPL (0.50) KDM4ELMNAALDH1A1HPGDSMN1; SMN2
SCHEMBL8400098 0.78 PIN1 (0.52) KDM4ELMNARAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2149503-A — — None — — JP disclosed
US-20220347173-A1 METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS BLADE THERAPEUTICS INC (US) 2022-11-03 — — US disclosed
US-20220324814-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS INC (US) 2022-10-13 — — US disclosed
US-11339130-B1 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2022-05-24 — — US disclosed
US-11339130-B1 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2022-05-24 — — US disclosed
EP-3820864-A1 METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS Blade Therapeutics, Inc. (US) 2021-05-19 — — EP disclosed
CN-112703188-A Method for treating liver fibrosis using calpain inhibitor 布莱德治疗公司 2021-04-23 — — CN disclosed
US-10934261-B2 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2021-03-02 — — US disclosed
US-10934261-B2 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2021-03-02 — — US disclosed
EP-3774737-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF Blade Therapeutics, Inc. (US) 2021-02-17 — — EP disclosed
US-10894776-B2 — — 2021-01-19 — — US disclosed
US-10894776-B2 — — 2021-01-19 — — US disclosed
US-20210009564-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPERTICS INC (US) 2021-01-14 — — US disclosed
US-20210009564-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPERTICS INC (US) 2021-01-14 — — US disclosed
CN-112204014-A Calpain modulators and therapeutic uses thereof 布莱德治疗公司 2021-01-08 — — CN disclosed
US-20200123114-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2020-04-23 — — US disclosed
WO-2019190885-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2019-10-03 — — WO disclosed
CN-110023304-A Calpain regulator and its therapeutical uses 布莱德治疗公司 2019-07-16 — — CN disclosed
WO-2018064119-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2018-04-05 — — WO disclosed
JP-H02149503-A MICROORGANISM-KILLING AGENT TOSOH CORP 1990-06-08 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200123114-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF CAPNS1, CAPN9, CAPN1 KDM4E 3495/4885LMNA 1415/4885RAB9A 2461/4885
US-10934261-B2 Calpain modulators and therapeutic uses thereof CAPNS1, CAPN9, CAPN1 KDM4E 3495/4885LMNA 1415/4885RAB9A 2461/4885
US-20220347173-A1 METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS CAPNS1, CAPN9, CAPN2 KDM4E 2666/4885LMNA 829/4885RAB9A 2764/4885
US-20210009564-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF CAPNS1, CAPN9, CAPN1 KDM4E 3635/4885LMNA 674/4885RAB9A 1960/4885
US-10894776-B2 — CAPNS1, CAPN9, CAPN2 KDM4E 3117/4885LMNA 1105/4885RAB9A 2055/4885
US-11339130-B1 Calpain modulators and therapeutic uses thereof CAPNS1, CAPN9, CAPN1 KDM4E 3495/4885LMNA 1415/4885RAB9A 2461/4885
US-20220324814-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF CAPNS1, CAPN9, CAPN1 KDM4E 3495/4885LMNA 1415/4885RAB9A 2461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.