Sugi Predict

Sugi Predict / Compounds / SCHEMBL10351

SCHEMBL10351

SCHEMBL10351

Nc1ccc(CCC(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ GFER P55789 1/20 0.59
▸ MAOB P27338 7/20 0.50
▸ MAOA P21397 2/20 0.50
▸ ALDH1A1 P00352 2/20 0.46
▸ TDP1 Q9NUW8 2/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ TSHR P16473 1/20 0.46
▸ TAAR1 Q96RJ0 2/20 0.45
▸ LOXL2 Q9Y4K0 1/20 0.44
▸ CYP19A1 P11511 3/20 0.43
▸ RECQL P46063 1/20 0.42
▸ MEN1 O00255 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2561293 0.98 GFER (0.56) GFERMAOBMAOAALDH1A1TDP1
SCHEMBL11130634 0.87 TAAR1 (0.42) GFERMAOBTAAR1
SCHEMBL4047436 0.78 TAAR1 (0.52) MAOBTAAR1LOXL2
SCHEMBL12340310 0.77 ESR1 (0.50) GFERTAAR1
SCHEMBL10570 0.77 ALDH1A1 (0.52) GFERMAOBMAOAALDH1A1TDP1
SCHEMBL13499925 0.76 CYP1A2 (0.50) ALDH1A1TDP1TAAR1MEN1MAPT
SCHEMBL7388083 0.76 GFER (0.59) GFERMAOBMAOAALDH1A1TDP1
SCHEMBL11059680 0.76 TAAR1 (0.50) MAOBALDH1A1TAAR1KDM4E
SCHEMBL11103061 0.76 TAAR1 (0.50) TAAR1
SCHEMBL147651 0.76 TAAR1 (0.61) MAOBALDH1A1TAAR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111321480-B Low-dielectric polyimide fiber, preparation method and application 航天科工(长沙)新材料研究院有限公司 2022-10-21 — — CN claimed
CN-114230790-A Polyimide powder and preparation method thereof 长沙新材料产业研究院有限公司 2022-03-25 — — CN claimed
CN-111321480-A Low-dielectric polyimide fiber, preparation method and application 长沙新材料产业研究院有限公司 2020-06-23 — — CN claimed
CN-111321480-B Low-dielectric polyimide fiber, preparation method and application 航天科工(长沙)新材料研究院有限公司 2022-10-21 — — CN disclosed
CN-114230790-A Polyimide powder and preparation method thereof 长沙新材料产业研究院有限公司 2022-03-25 — — CN disclosed
CN-111321480-A Low-dielectric polyimide fiber, preparation method and application 长沙新材料产业研究院有限公司 2020-06-23 — — CN disclosed
EP-2792667-B1 DIPHENYLAMINE COMPOUND AND METHOD FOR PRODUCING SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 2018-02-07 — — EP disclosed
US-9550724-B2 Diphenylamine compounds and production method thereof IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2017-01-24 — — US disclosed
CN-102858743-B Spiro-condensed cyclohexane derivatives as HSL inhibitors useful for the treatment of diabetes HOFFMANN LA ROCHE 2015-06-10 — — CN disclosed
EP-2488493-B1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES HOFFMANN LA ROCHE (CH) 2015-04-15 — — EP disclosed
US-20140336415-A1 DIPHENYLAMINE COMPOUNDS AND PRODUCTION METHOD THEREOF IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2014-11-13 — — US disclosed
EP-2488493-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-08-22 — — EP disclosed
EP-2393811-A1 4-AMINO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE DERIVATIVES Pfizer Inc. (US) 2011-12-14 — — EP disclosed
EP-2382218-A1 DELTA-5-DESATURASE INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2011-11-02 — — EP disclosed
US-20110092512-A1 NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 — — US disclosed
WO-2011045292-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 — — WO disclosed
WO-2010089686-A1 4-AMINO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE DERIVATIVES PFIZER INC. (US) 2010-08-12 — — WO disclosed
WO-2010087467-A1 DELTA-5-DESATURASE INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-08-05 — — WO disclosed
US-20100197591-A1 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES PFIZER INC 2010-08-05 — — US disclosed
US-20100190747-A1 Fused ring compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-07-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100197591-A1 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES CDK7, DPYD, DHFR GFER 4195/4885MAOB 1238/4885MAOA 1935/4885
US-20140336415-A1 DIPHENYLAMINE COMPOUNDS AND PRODUCTION METHOD THEREOF DDT, PAH, DDC GFER 1028/4885MAOB 47/4885MAOA 78/4885
US-20100190747-A1 Fused ring compound and use thereof CYP46A1, LTB4R2, PTGES GFER 1307/4885MAOB 2248/4885MAOA 2482/4885
US-20110092512-A1 NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES LPL, MGLL, LIPE GFER 1262/4885MAOB 2380/4885MAOA 2520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.