Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | AGXT | P21549 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | PPM1D | O15297 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31304968 | 1.00 | LOXL2 (0.51) | LOXL2ADRA2AAGXTHTR2BHTR1A | |
| SCHEMBL7791747 | 0.91 | LOXL2 (0.56) | LOXL2ADRA2AAGXTHTR2BHTR1A | |
| SCHEMBL2905181 | 0.80 | ADRA2A (0.46) | LOXL2ADRA2AAGXTHTR2BHTR1A | |
| SCHEMBL2906664 | 0.79 | VCP (0.45) | LOXL2ADRA2AAGXTHTR2BHTR1A | |
| SCHEMBL24227281 | 0.78 | SIGMAR1 (0.58) | RAB9ANPC1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7339656 | 0.78 | AAK1 (0.33) | ADRA2ARAB9AALDH1A1 | |
| SCHEMBL1257003 | 0.78 | ADRA2A (0.57) | LOXL2ADRA2AAGXTHTR2BHTR1A | |
| SCHEMBL28045623 | 0.78 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1311757 | 0.77 | CA12 (0.44) | LOXL2RAB9ANPC1 | |
| SCHEMBL7344747 | 0.76 | AAK1 (0.34) | LOXL2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0207605-A1 | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |