Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791747 | 0.88 | LOXL2 (0.56) | ADRA2ALOXL2AGXTHTR2BHTR1A | |
| SCHEMBL10366180 | 0.80 | LOXL2 (0.51) | ADRA2ALOXL2AGXTHTR2BHTR1A | |
| SCHEMBL31304968 | 0.80 | LOXL2 (0.51) | ADRA2ALOXL2AGXTHTR2BHTR1A | |
| SCHEMBL2906664 | 0.79 | VCP (0.45) | ADRA2ALOXL2AGXTHTR2BHTR1A | |
| SCHEMBL979289 | 0.75 | ACHE (0.60) | CYP2A6BCHEACHESLC6A2SLC6A4 | |
| SCHEMBL18528970 | 0.72 | LOXL2 (0.53) | ADRA2ALOXL2AGXTHTR2BHTR1A | |
| SCHEMBL28732114 | 0.70 | GBA1 (0.53) | — | |
| SCHEMBL112634 | 0.70 | LOXL2 (0.58) | ADRA2ALOXL2AGXTCYP2A6HTR2B | |
| SCHEMBL14045098 | 0.68 | LOXL2 (0.51) | LOXL2AGXTCYP2A6HTR2BHTR1A | |
| SCHEMBL1256835 | 0.68 | ADRA2A (0.58) | ADRA2ALOXL2AGXTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217566-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009064250-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009064251-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | disclosed |