Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 8/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791747 | 0.87 | LOXL2 (0.56) | ADRA2ALOXL2PREPSLC6A4HTR1A | |
| SCHEMBL31304968 | 0.79 | LOXL2 (0.51) | ADRA2ALOXL2PREPHTR1AHTR2B | |
| SCHEMBL10366180 | 0.79 | LOXL2 (0.51) | ADRA2ALOXL2PREPHTR1AHTR2B | |
| SCHEMBL2905181 | 0.79 | ADRA2A (0.46) | ADRA2ALOXL2PREPSLC6A2SLC6A4 | |
| SCHEMBL979273 | 0.75 | ACHE (0.59) | SLC6A2SLC6A4MEN1KMT2AFLT3 | |
| SCHEMBL2905520 | 0.75 | PTGES2 (0.40) | ADRA2ALOXL2SLC6A2SLC6A4ESR1 | |
| SCHEMBL1662783 | 0.72 | GBA1 (0.53) | HTR2BMEN1KMT2A | |
| SCHEMBL3515654 | 0.72 | GBA1 (0.53) | HTR2BMEN1KMT2A | |
| SCHEMBL18528970 | 0.71 | LOXL2 (0.53) | ADRA2ALOXL2PREPSLC6A4HTR1A | |
| SCHEMBL1650806 | 0.71 | ESR1 (0.57) | LOXL2PREPHTR1AHTR2BESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217566-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009064250-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009064251-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | disclosed |