Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851486 | 0.88 | HPGD (0.62) | ALDH1A1EPHX2HTTHPGDFAAH | |
| SCHEMBL19851687 | 0.88 | HPGD (0.62) | ALDH1A1EPHX2HTTHPGDFAAH | |
| SCHEMBL10382127 | 0.86 | ALDH1A1 (0.53) | ALDH1A1EPHX2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL13073335 | 0.85 | EPHX1 (0.62) | ALDH1A1EPHX2L3MBTL1KDM4EGAA | |
| SCHEMBL7749669 | 0.84 | GAA (0.63) | ALDH1A1HTTRECQLHPGDMEN1 | |
| SCHEMBL17117331 | 0.82 | L3MBTL1 (0.68) | ALDH1A1EPHX2CYP2C19L3MBTL1HPGD | |
| SCHEMBL19851487 | 0.81 | SMN1; SMN2 (0.59) | ALDH1A1L3MBTL1HTTRECQLHPGD | |
| SCHEMBL19851737 | 0.81 | TLR2 (0.56) | EPHX2RECQLHPGDKDM4EFAAH | |
| SCHEMBL19851489 | 0.81 | TSHR (0.55) | ALDH1A1EPHX2RECQLHPGDKDM4E | |
| SCHEMBL30074498 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HTTRECQLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990006928-A1 | 6-(1-CARBAMOYL-1-HYDROXYMETHYL)PENICILLANIC ACID DERIVATIVES | BARTH WAYNE E (US) | 1990-06-28 | — | — | WO | disclosed |
| US-4868296-A | 6-(1-carbamoyl-1-hydroxymethyl) penicillanic acid derivatives | PFIZER INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4797394-A | 6-(1-carbamoyl-1-hydroxymethyl)penicillanic acid derivatives | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0220939-A1 | 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic-acid derivatives | PFIZER INC. (US) | 1987-05-06 | — | — | EP | disclosed |