Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.53 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL10401426 | 1.00 | RAB9A (0.61) | RAB9ACHRM4ALDH1A1MEN1KMT2A | |
| SCHEMBL10401770 | 0.93 | CHRM4 (0.57) | CHRM4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10401826 | 0.83 | DRD2 (0.62) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL10401540 | 0.82 | CHRM4 (0.55) | CHRM4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10402030 | 0.81 | MEN1 (0.49) | CHRM4MEN1KMT2AMAPTSMN1; SMN2 | |
| Oxalic Acid SCHEMBL10401881 | 0.81 | CHRM4 (0.54) | CHRM4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10401849 | 0.81 | CHRM4 (0.54) | CHRM4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10401429 | 0.80 | KMT2A (0.56) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL10401899 | 0.80 | MEN1 (0.48) | CHRM4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL10401384 | 0.80 | SMN1; SMN2 (0.62) | RAB9AALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4960776-A | ANTIALLERGENS | A. H. ROBINS COMPANY, INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0277725-A2 | 4-Aryl-N-[2-(dialkylamino and heterocyclicamino) alkyl]-1-piperazinecarboxamides and their use as anti allergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-10 | — | — | EP | disclosed |