Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12611697 | 0.75 | P2RX7 (0.37) | GABRG2GABRB3GABRA5 | |
| SCHEMBL1041825 | 0.70 | ADRA1D (0.35) | — | |
| SCHEMBL28298056 | 0.70 | GABRG2 (0.40) | GABRG2GABRB3GABRA5EGLN2 | |
| SCHEMBL15398023 | 0.67 | ADRA1A (0.39) | — | |
| SCHEMBL20799548 | 0.66 | ACHE (0.38) | — | |
| SCHEMBL10758728 | 0.64 | GABRG2 (0.36) | GABRG2GABRB3GABRA5EGLN2 | |
| SCHEMBL20684766 | 0.64 | GABRG2 (0.34) | GABRG2GABRB3GABRA5EGLN2 | |
| SCHEMBL21729074 | 0.60 | — | — | |
| SCHEMBL8275605 | 0.60 | CYP11B2 (0.34) | — | |
| SCHEMBL1930706 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |