Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17869621 | 0.77 | XDH (0.60) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL304096 | 0.71 | XDH (0.53) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL30491699 | 0.71 | XDH (0.53) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL10429308 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL24968162 | 0.71 | ALDH1A1 (0.50) | HTTALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL19342074 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL28253783 | 0.69 | ADORA3 (0.55) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL27172278 | 0.69 | RAB9A (0.71) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL11728795 | 0.68 | SMN1; SMN2 (1.00) | SMN1; SMN2HTTKMT2AALDH1A1MAPT | |
| SCHEMBL24035855 | 0.67 | ALDH1A1 (0.36) | SMN1; SMN2HTTKMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934299-B2 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | VALO EARLY DISCOVERY, INC. (US) | 2021-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934299-B2 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors | USP7, UBA7, UBXN1 | SMN1; SMN2 1782/4885HTT 1255/4885KMT2A 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.