Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586501 | 0.82 | HTR7 (0.48) | HTR7HTR1AKMT2ADRD2 | |
| SCHEMBL9528427 | 0.81 | HTR1A (0.46) | HTR7ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL27263291 | 0.79 | DRD2 (0.54) | HTR7ADRA1AHTR1AADRA1BDRD2 | |
| SCHEMBL9528463 | 0.78 | GAA (0.45) | HTR7ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL9527044 | 0.78 | HTR1A (0.63) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527544 | 0.74 | KAT2B (0.56) | — | |
| SCHEMBL9528402 | 0.72 | HTR1A (0.61) | HTR7ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL9527068 | 0.71 | HTR7 (0.40) | HTR7ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL27263078 | 0.71 | HTR1A (0.41) | HTR7ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL9527740 | 0.71 | DRD2 (0.64) | HTR7ADRA1AHTR1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |