Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528463 | 0.86 | GAA (0.45) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL27263634 | 0.81 | HTR1A (0.47) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL6586501 | 0.76 | HTR7 (0.48) | HTR1AHTR7 | |
| SCHEMBL9527044 | 0.75 | HTR1A (0.63) | HTR1AADRA1BADRA1DADRA1ADRD4 | |
| SCHEMBL27263186 | 0.74 | ALDH1A1 (0.47) | HTR1AADRA1BADRA1DADRA1ATRPC5 | |
| SCHEMBL27263871 | 0.73 | TSHR (0.48) | HTR1AADRA1BADRA1DADRA1AALDH1A1 | |
| SCHEMBL9527118 | 0.72 | HTR1A (0.52) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL10431149 | 0.71 | HTR7 (0.43) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL27263993 | 0.71 | HTR7 (0.43) | HTR1AADRA1BADRA1DADRA1AHTR7 | |
| SCHEMBL11447503 | 0.70 | HTR1A (0.51) | HTR1AADRA1AHTR7GAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |