Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263291 | 0.84 | DRD2 (0.54) | HTR7KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL9528463 | 0.83 | GAA (0.45) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL6179970 | 0.82 | PKM (0.59) | HTR7KCNH2KMT2ASMN1; SMN2HTR1A | |
| SCHEMBL10431149 | 0.82 | HTR7 (0.43) | HTR7KMT2AHTR1ADRD2 | |
| SCHEMBL9527044 | 0.81 | HTR1A (0.63) | HTR1ADRD2 | |
| SCHEMBL9528344 | 0.79 | ADRA1D (0.48) | HTR7KCNH2KMT2ASMN1; SMN2HTR1A | |
| SCHEMBL27263078 | 0.76 | HTR1A (0.41) | HTR7HTR1A | |
| SCHEMBL9528402 | 0.74 | HTR1A (0.61) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL5926097 | 0.74 | HTR7 (0.56) | HTR7KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL9527740 | 0.74 | DRD2 (0.64) | HTR7KMT2AHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430034-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Egis Gyogyszergyar Rt. (HU) | 2004-06-23 | — | — | EP | claimed |
| WO-2003027078-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2003-04-03 | — | — | WO | claimed |