Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364204 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL6380157 | 0.81 | ADRA1D (0.46) | ALDH1A1L3MBTL1MAPTATMADRA1D | |
| SCHEMBL6644379 | 0.81 | P2RX7 (0.56) | ALDH1A1L3MBTL1MAPTATMTDP1 | |
| SCHEMBL2572955 | 0.81 | NAPRT (0.58) | ALDH1A1L3MBTL1MAPTATMADRA1D | |
| SCHEMBL8237046 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2201670 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAL3MBTL1KMT2APOLB | |
| SCHEMBL17007538 | 0.80 | HCRTR1 (0.46) | ALDH1A1L3MBTL1MAPTATMADRA1D | |
| SCHEMBL9359025 | 0.80 | KEAP1 (0.48) | ALDH1A1L3MBTL1MAPTATMADRA1D | |
| SCHEMBL8647199 | 0.80 | LMNA (0.51) | SMN1; SMN2LMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL14498467 | 0.79 | LMNA (0.44) | SMN1; SMN2LMNAALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260092-B | Synthesis method of 2-chloronicotinamide and N-substituted derivative thereof | 山东京博生物科技有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-115260092-A | Synthesis method of 2-chloronicotinamide and N-substituted derivative thereof | 山东京博生物科技有限公司 | 2022-11-01 | — | — | CN | disclosed |
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| US-8349827-B2 | Substituted dipyrido-pyrimido-diazepine and benzo-pyrido-pyrimido compounds | ARQULE, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2012-12-27 | — | — | US | disclosed |
| EP-2270014-A1 | Azepine inhibitors of janus kinases | Incyte Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| US-20100249108-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| WO-2007038215-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |
| EP-0532058-B1 | Process for preparing halogenosulfonyl-substituted pyridine compounds | ISHIHARA SANGYO KAISHA (JP) | 1994-12-14 | — | — | EP | disclosed |
| EP-0298752-B1 | Mercapto-substituted pyridine compounds and process for preparing the same | ISHIHARA SANGYO KAISHA (JP) | 1994-02-02 | — | — | EP | disclosed |
| EP-0532058-A1 | Process for preparing halogenosulfonyl-substituted pyridine compounds | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5168113-A | Intermediates for herbicides | ISHIHARA SANGYO KAISHA LTD. (JP) | 1992-12-01 | — | — | US | disclosed |
| US-5128474-A | Herbicides | ISHIHARA SANGYO KAISHA LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| US-5079363-A | From an alkoxypyridine and an indole derivative, antitumor and antileukemia agents | SANOFI (FR) | 1992-01-07 | — | — | US | disclosed |
| EP-0298752-A2 | Mercapto-substituted pyridine compounds and process for preparing the same | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | SMN1; SMN2 3556/4885LMNA 4785/4885ALDH1A1 3705/4885 |
| US-20100249108-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | PDXK, DPYD, DHFR | SMN1; SMN2 1175/4885LMNA 2600/4885ALDH1A1 873/4885 |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | SMN1; SMN2 3556/4885LMNA 4785/4885ALDH1A1 3705/4885 |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | SMN1; SMN2 3556/4885LMNA 4785/4885ALDH1A1 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.