Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27508355 | 0.87 | SCN5A (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL1133623 | 0.87 | SCN5A (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL10709944 | 0.84 | OPRM1 (0.45) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL8720644 | 0.82 | HDAC1 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21269749 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21268815 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21269197 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21269903 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21270032 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 | |
| SCHEMBL21269530 | 0.81 | CES2 (0.46) | CES2CES1SCN5ASCN9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991643-B1 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | BASF SE (DE) | 2019-10-30 | — | — | EP | disclosed |
| US-10062471-B2 | Additive formulation suitable for antistatic modification and improving the electrical conductivity of inanimate organic material | BASF SE (DE) | 2018-08-28 | — | — | US | disclosed |
| EP-3263563-A1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS FUEL ADDITIVE OR LUBRICANT ADDITIVE | BASF SE (DE) | 2018-01-03 | — | — | EP | disclosed |
| EP-2649054-B1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND THEIR USE AS FUEL ADDITIVES OR LUBRICANT ADDITIVE | BASF SE (DE) | 2017-07-12 | — | — | EP | disclosed |
| US-9670430-B2 | Synergistic mixture | BASF SE (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9562202-B2 | Synergistic mixture | BASF SE (DE) | 2017-02-07 | — | — | US | disclosed |
| US-9359570-B2 | Polytetrahydrobenzoxazines and bistetrahydrobenzoxazines and use thereof as a fuel additive or lubricant additive | BASF SE (DE) | 2016-06-07 | — | — | US | disclosed |
| US-9315759-B2 | Synergistic mixture | BASF SE (DE) | 2016-04-19 | — | — | US | disclosed |
| US-20160090541-A1 | SYNERGISTIC MIXTURE | BASF SE (DE) | 2016-03-31 | — | — | US | disclosed |
| US-20150152349-A1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS A FUEL ADDITIVE OR LUBRICANT ADDITIVE | BASF SE (DE) | 2015-06-04 | — | — | US | disclosed |
| US-20120149617-A1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS A FUEL ADDITIVE OR LUBRICANT ADDITIVE | BASF SE (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20110113678-A1 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | BASF SE (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110034360-A1 | ALPHA-OLEFIN/ISOBUTENE DIBLOCK COPOLYMERS | BASE SE (DE) | 2011-02-10 | — | — | US | disclosed |
| EP-2272821-A2 | Trinuclear phenolic compounds | BASF SE (DE) | 2011-01-12 | — | — | EP | disclosed |
| EP-2267104-A2 | Use of polynuclear phenolic compounds as dispersants | BASF SE (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2132284-B1 | ADDITIVE FORMULATION SUITED FOR ANTI-STATIC FINISHING AND IMPROVEMENT OF THE ELECTRICAL CONDUCTIVITY OF INANIMATE ORGANIC MATERIAL | BASF SE (DE) | 2010-12-01 | — | — | EP | disclosed |
| US-20100210492-A1 | SYNERGISTIC MIXTURE | BASF SE (DE) | 2010-08-19 | — | — | US | disclosed |
| US-20100072427-A1 | ADDITIVE FORMULATION SUITABLE FOR ANTISTATIC MODIFICATION AND IMPROVING THE ELECTRICAL CONDUCTIVITY OF INANIMATE ORGANIC MATERIAL | BASF SE (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20090065744-A1 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | BASF SE (DE) | 2009-03-12 | — | — | US | disclosed |
| US-5108631-A | Method of overbasing with a hydroxy sulfonic acid copromoter | THE LUBRIZOL CORPORATION (US) | 1992-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090065744-A1 | USE OF POLYNUCLEAR PHENOLIC COMPOUNDS AS STABILISERS | TYR, COMT, AHR | CES2 3911/4885CES1 4680/4885SCN5A 4269/4885 |
| US-20120149617-A1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS A FUEL ADDITIVE OR LUBRICANT ADDITIVE | ADH1A, ADH1C, H1-0 | CES2 739/4885CES1 1954/4885SCN5A 1833/4885 |
| US-20150152349-A1 | POLYTETRAHYDROBENZOXAZINES AND BISTETRAHYDROBENZOXAZINES AND USE THEREOF AS A FUEL ADDITIVE OR LUBRICANT ADDITIVE | ADH1A, ADH1C, H1-0 | CES2 739/4885CES1 1954/4885SCN5A 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.