SCHEMBL1045097

SCHEMBL1045097

Cc1cccc(-c2cc[c]cc2F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.44
AKR1C2 P52895 1/20 0.44
RPS6KA3 P51812 1/20 0.41
ACHE P22303 2/20 0.39
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
MAOB P27338 1/20 0.36
AR P10275 1/20 0.36
ADORA1 P30542 2/20 0.35
ADORA2A P29274 1/20 0.35
RAB9A P51151 3/20 0.35
CNR2 P34972 2/20 0.35
NPC1 O15118 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CNR1 P21554 1/20 0.35
TP53 P04637 1/20 0.35
CHEK1 O14757 1/20 0.35
MAP4K4 O95819 1/20 0.35
ABL1 P00519 1/20 0.35
NTRK1 P04629 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4209132 0.82 TAAR1 (0.40) PDE3BPDE3AMAP4K4PIM1PRKACA
SCHEMBL5634702 0.82 ACHE (0.39) ACHEMAOBADORA1ADORA2ARAB9A
SCHEMBL16720374 0.79 CNR2 (0.51) RPS6KA3ACHECNR2CNR1
SCHEMBL9284243 0.79 TDO2 (0.38) MAOBADORA1ADORA2ARAB9ANPC1
SCHEMBL5506756 0.79 AKR1C3 (0.48) AKR1C3AKR1C2RPS6KA3MAOBAR
SCHEMBL1804627 0.79 AKR1C3 (0.36) AKR1C3AKR1C2RPS6KA3ACHEMAOB
SCHEMBL29019397 0.78 PTGS2 (0.40) RPS6KA3ACHEPDE3BPDE3ARAB9A
SCHEMBL693886 0.77 MEN1 (0.35) AKR1C3AKR1C2RPS6KA3RAB9ANPC1
SCHEMBL29019414 0.77 AKR1C3 (0.43) AKR1C3AKR1C2PDE3BPDE3ATP53
SCHEMBL8093287 0.77 CYP1A1 (0.44) ACHEMAOBARRAB9ACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109851602-B 14-deoxy-11,12-dehydro-8,12-epoxy-andrographolide and 15-substituted derivatives thereof 郑州大学 2023-04-11 CN claimed
EP-3169666-A1 SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES Grünenthal GmbH (DE) 2017-05-24 EP disclosed
EP-3169665-A1 SUBSTITUTED AZA-SPIRO(4.5)DECAN-DERIVATIVES Grünenthal GmbH (DE) 2017-05-24 EP disclosed
WO-2016008583-A1 SUBSTITUTED AZA-SPIRO(4.5)DECAN-DERIVATIVES Grünenthal GmbH (DE) 2016-01-21 WO disclosed
WO-2016008582-A1 SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES Grünenthal GmbH (DE) 2016-01-21 WO disclosed
EP-2280941-A1 (HETERO-)ARYL CYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2011-02-09 EP disclosed
EP-2271613-A1 HYDROXYMETHYLCYCLOHEXYL AMINES Grünenthal GmbH (DE) 2011-01-12 EP disclosed
EP-2260022-A1 SUBSTITUTED CYCLOHEXYLDIAMINES Grünenthal GmbH (DE) 2010-12-15 EP disclosed
EP-2260042-A1 SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2010-12-15 EP disclosed
EP-2260021-A1 SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2010-12-15 EP disclosed
EP-2257526-A1 SPIRO(5.5)UNDECANE DERIVATIVES Grünenthal GmbH (DE) 2010-12-08 EP disclosed
WO-2009118171-A1 HYDROXYMETHYLCYCLOHEXYL AMINES Grünenthal GmbH (DE) 2009-10-01 WO disclosed
WO-2009118173-A1 SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2009-10-01 WO disclosed
WO-2009118169-A1 SPIRO(5.5)UNDECANE DERIVATIVES Grünenthal GmbH (DE) 2009-10-01 WO disclosed
WO-2009118163-A1 (HETERO-)ARYL CYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2009-10-01 WO disclosed
WO-2009118174-A1 SUBSTITUTED CYCLOHEXYLDIAMINES Grünenthal GmbH (DE) 2009-10-01 WO disclosed
WO-2009118168-A1 SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES Grünenthal GmbH (DE) 2009-10-01 WO disclosed