Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | FABP2 | P12104 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29246765 | 0.98 | PTGS1 (0.34) | MEN1KMT2APTGS1PTGS2HPGD | |
| SCHEMBL28530737 | 0.92 | ALDH1A1 (0.33) | MEN1KMT2APTGS1PTGS2HPGD | |
| SCHEMBL4319544 | 0.86 | — | — | |
| SCHEMBL5116498 | 0.83 | BACE1 (0.34) | MEN1KMT2APTGS1PTGS2HPGD | |
| SCHEMBL150097 | 0.83 | PTGS2 (0.35) | PTGS1PTGS2CYP2C9CYP2C19RPS6KA3 | |
| SCHEMBL2886283 | 0.81 | — | — | |
| SCHEMBL4209132 | 0.80 | TAAR1 (0.40) | MEN1KMT2AHPGDMAPT | |
| SCHEMBL434024 | 0.80 | KDM4E (0.34) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL618853 | 0.79 | BACE1 (0.39) | PTGS2HPGDBACE1ALDH1A1HSD17B10 | |
| SCHEMBL15286357 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654610-A | Pyrazole and imidazole compounds for inhibiting IL-17 and ROR gamma | 里亚塔医药公司 | 2021-04-13 | — | — | CN | claimed |
| US-10076517-B2 | Methods and pharmaceutical compositions for the treatment of fibrosis | INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE KA RECHERCHE MÉDICALE (FR) | 2018-09-18 | — | — | US | claimed |
| WO-2015114030-A1 | ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT AND/OR PROPHYLAXIS OF HEART DISEASES | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN (DE) | 2015-08-06 | — | — | WO | claimed |
| US-8815839-B2 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-08-26 | — | — | US | claimed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | claimed |
| US-8691805-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-04-08 | — | — | US | claimed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | claimed |
| US-20130244997-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (US) | 2013-09-19 | — | — | US | claimed |
| US-20130184251-A1 | HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-07-18 | — | — | US | claimed |
| US-8455476-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2013-06-04 | — | — | US | claimed |
| WO-1987000519-A1 | CHEMICAL COMPOUNDS COMRPISING SUBSTITUTED PHENYLRINGS | THE UPJOHN COMPANY (US) | 1987-01-29 | — | — | WO | claimed |
| EP-0207622-A2 | Benzothiazine dioxide derivatives | PFIZER INC. (US) | 1987-01-07 | — | — | EP | claimed |
| US-4610982-A | Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor | PFIZER INC. (US) | 1986-09-09 | — | — | US | claimed |
| US-4601797-A | Electrochemical carboxylation of p-isobutylacetophenone and other aryl ketones | MONSANTO COMPANY (US) | 1986-07-22 | — | — | US | claimed |
| US-4188491-A | PREPARING 2-(4-BIPHENYLYL)PROPIONIC ACIDS BY REACTING BIPHENYLYLMAGNESIUM BROMIDES WITH SODIUM PYRUVATE, ACIDIFYING | THE BOOTS COMPANY LIMITED (GB) | 1980-02-12 | — | — | US | claimed |
| US-4107439-A | Process for preparing arylalkanoic acid derivatives | THE UPJOHN COMPANY (US) | 1978-08-15 | — | — | US | claimed |
| US-4096338-A | ANTIPHLOGISTIC | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1978-06-20 | — | — | US | claimed |
| US-4042617-A | FROM A GLYCIDIC ACID ESTER | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1977-08-16 | — | — | US | claimed |
| US-4016196-A | HEATING GLYCIDIC ESTERS | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1977-04-05 | — | — | US | claimed |
| US-4007217-A | FROM A GLYCIDATE | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1977-02-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10076517-B2 | Methods and pharmaceutical compositions for the treatment of fibrosis | LIPA, MGLL, PNLIP | MEN1 3362/4885KMT2A 2612/4885PTGS1 422/4885 |
| US-20130244997-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | PNLIP, LPL, LIPA | MEN1 1953/4885KMT2A 1573/4885PTGS1 376/4885 |
| US-20130184251-A1 | HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | MGLL, PNLIP, LIPC | MEN1 4471/4885KMT2A 780/4885PTGS1 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.