4-(Isobutylsulfonyl)Pyridin-2-Yl Methanesulfonate

4-(Isobutylsulfonyl)Pyridin-2-Yl Methanesulfonate

SCHEMBL10462154

CC(C)CS(=O)(=O)c1ccnc(OS(C)(=O)=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.33
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33
AAK1 Q2M2I8 1/20 0.32
RORC P51449 1/20 0.32
IL17A Q16552 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32
MMP14 P50281 1/20 0.32
LOX P28300 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MMP13 P45452 2/20 0.31
HRH4 Q9H3N8 2/20 0.31
MMP1 P03956 1/20 0.31
LNPEP Q9UIQ6 1/20 0.30
JAK2 O60674 1/20 0.30
TYK2 P29597 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9869208 0.77 ALDH1A1 (0.43) KDM4ESMN1; SMN2
4-(Isobutylthio)Pyridin-2-Yl Methanesulfonate SCHEMBL10462292 0.73 TSHR (0.35) AAK1LOXLOXL2KDM4EPOLB
SCHEMBL5700299 0.64 SMN1; SMN2 (0.50) NR1H2NR1H3LOXLOXL2KDM4E
SCHEMBL11447471 0.64 ALDH1A1 (0.39) KDM4ESMN1; SMN2MMP13MMP1
SCHEMBL11130878 0.64 KYNU (0.37) PTGDR2KDM4EMMP13MMP1
SCHEMBL1360826 0.63 LMNA (0.41) KDM4EPOLBSMN1; SMN2
SCHEMBL2705523 0.63 ALDH1A1 (0.54) KDM4ESMN1; SMN2
SCHEMBL25227918 0.63 ALDH1A1 (0.42)
SCHEMBL778303 0.62 PSIP1 (0.60) POLBSMN1; SMN2
SCHEMBL11554272 0.62 PTGS2 (0.40) KDM4EPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4950679-A Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-08-21 US disclosed
US-4791127-A Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1988-12-13 US disclosed
EP-0245944-A2 Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-11-19 EP disclosed
EP-0220857-A1 Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides Nippon Kayaku Kabushiki Kaisha (JP) 1987-05-06 EP disclosed