SCHEMBL778303

SCHEMBL778303

CC(C)CS(=O)(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PSIP1 O75475 1/20 0.60
HSD11B1 P28845 6/20 0.47
POLB P06746 1/20 0.46
TP53 P04637 2/20 0.44
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
HTR6 P50406 1/20 0.44
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP1A2 P05177 1/20 0.42
GAA P10253 1/20 0.42
CYP2C19 P33261 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
LARS1 Q9P2J5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2703745 0.88 MMP2 (0.55) PSIP1
SCHEMBL2705059 0.83 LARS1 (0.51) PSIP1TP53ALDH1A1MAPTTHRB
SCHEMBL8909374 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL8910619 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL27596821 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL9426107 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL1972951 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL7724605 0.83 PSIP1 (0.56) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL15214393 0.82 PSIP1 (0.50) PSIP1HSD11B1POLBTP53ALDH1A1
SCHEMBL2444476 0.81 PSIP1 (0.59) PSIP1HSD11B1POLBTP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113707933-A Preparation method of solid electrolyte nano dispersion liquid of lithium ion battery and solid electrolyte nano dispersion liquid 北京卫蓝新能源科技有限公司 2021-11-26 CN claimed
US-12100809-B2 Non-aqueous liquid electrolyte and non-aqueous liquid electrolyte secondary battery MITSUBISHI CHEMICAL CORPORATION (JP) 2024-09-24 US disclosed
US-20240308989-A1 PYRAN DERIVATIVES AS CYP11A1 (CYTOCHROME P450 MONOOXYGENASE 11A1) INHIBITORS ORION CORP (FI) 2024-09-19 US disclosed
US-20240239774-A1 SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF CORNELL UNIVERSITY (US) 2024-07-18 US disclosed
US-12030871-B2 Pyran dervatives as CYP11A1 (cytochrome P450 monooxygenase 11A1) inhibitors ORION CORPORATION (FI) 2024-07-09 US disclosed
US-11814388-B1 Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers FERRIS STATE UNIVERSITY (US) 2023-11-14 US disclosed
US-20230348369-A1 NAMPT MODULATORS CYTOKINETICS, INC. 2023-11-02 US disclosed
US-20230348369-A1 NAMPT MODULATORS CYTOKINETICS, INC. 2023-11-02 US disclosed
US-20230321050-A1 Heterocyclic Compounds and Uses Thereof MILLENNIUM PHARMACEUTICALS, INC. 2023-10-12 US disclosed
EP-3350165-B1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ORGANOVO INC (US) 2023-07-26 EP disclosed
US-5266577-A Method of treating congestive heart failure using carbostyril derivatives OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) 1993-11-30 US disclosed
US-5198448-A Cardiovascular disorders OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1993-03-30 US disclosed
EP-0480986-A1 6-(HYDRONAPHTYL-1-ETHYL)-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES AND THE CORRESPONDING HYDROXY ACIDS BRITISH BIO-TECHNOLOGY LIMITED (GB) 1992-04-22 EP disclosed
US-5053514-A Side effect reduction; carbostyril derivatives OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1991-10-01 US disclosed
WO-1991000280-A1 6-(HYDRONAPHTYL-1-ETHYL)-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES AND THE CORRESPONDING HYDROXY ACIDS BRITISH BIO-TECHNOLOGY LIMITED (GB) 1991-01-10 WO disclosed
EP-0367393-A2 New heterocyclic compounds, production and use thereof Takeda Chemical Industries, Ltd. (JP) 1990-05-09 EP disclosed
US-4420433-A REACTION WITH SILICON TETRACHLORIDE OR TITANIUM TETRACHLORIDE BAYER AKTIENGESELLSCHAFT (DE) 1983-12-13 US disclosed
EP-0071065-A1 Process for the preparation of fluorine-substituted carboxylic-acid chlorides and aldehydes BAYER AG (DE) 1983-02-09 EP disclosed
US-4166866-A Immunosuppressive method with dithiocarbamates THE CALIFORNIA POLYTECHNIC STATE UNIVERSITY FOUNDATION (US) 1979-09-04 US disclosed
US-4130578-A Immunosuppressive dithiocarbanilates THE UPJOHN COMPANY (US) 1978-12-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230321050-A1 Heterocyclic Compounds and Uses Thereof PIK3CA, PIK3CD, PIK3CB PSIP1 3815/4885HSD11B1 1906/4885POLB 2432/4885
US-20240239774-A1 SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF UACA, ADCYAP1R1, ADCY1 PSIP1 2086/4885HSD11B1 62/4885POLB 3155/4885
US-20230348369-A1 NAMPT MODULATORS NAMPT, NNT, NAPRT PSIP1 2126/4885HSD11B1 853/4885POLB 4018/4885
US-12030871-B2 Pyran dervatives as CYP11A1 (cytochrome P450 monooxygenase 11A1) inhibitors CYP11B1, CYP11B2, CYP4A11 PSIP1 2752/4885HSD11B1 16/4885POLB 1548/4885
US-20240308989-A1 PYRAN DERIVATIVES AS CYP11A1 (CYTOCHROME P450 MONOOXYGENASE 11A1) INHIBITORS CYP11B1, CYP11B2, CYP4A11 PSIP1 2420/4885HSD11B1 24/4885POLB 1797/4885
US-11814388-B1 Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers AURKA, AURKC, AURKB PSIP1 1200/4885HSD11B1 2577/4885POLB 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.