Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | ALPL | P05186 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516186 | 0.81 | RIPK1 (0.71) | SMN1; SMN2ALDH1A1ALOX12GAAPOLB | |
| SCHEMBL11374387 | 0.80 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| SCHEMBL10480438 | 0.79 | LMNA (0.72) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| Pivhydrazine SCHEMBL149084 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1ALOX12POLBLMNA | |
| SCHEMBL10480392 | 0.78 | GAA (0.81) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| Pivhydrazine SCHEMBL9551290 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1ALOX12POLBLMNA | |
| SCHEMBL1275902 | 0.75 | ALOX12 (1.00) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| SCHEMBL10480376 | 0.75 | POLB (0.74) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| SCHEMBL11356477 | 0.75 | GAA (0.69) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD | |
| SCHEMBL11503706 | 0.75 | RAB9A (0.70) | SMN1; SMN2ALDH1A1ALOX12GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989006125-A1 | 4-ARALKYL-5-SUBSTITUTED-1,2,4-TRIAZOLE-5-THIOLS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0323737-A1 | 4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols | SMITHKLINE BEECHAM CORPORATION (US) | 1989-07-12 | — | — | EP | disclosed |