Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 7/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277310 | 0.72 | HSD17B10 (0.46) | HSD17B10KDM4EMETAP2BRAFPARP15 | |
| SCHEMBL7070839 | 0.72 | KDM4E (0.50) | HSD17B10KDM4EMETAP2BRAFPARP15 | |
| SCHEMBL8691865 | 0.69 | KDM4E (0.43) | HSD17B10KDM4EMETAP2BRAFPARP15 | |
| SCHEMBL7072330 | 0.68 | BRAF (0.58) | HSD17B10KDM4EBRAFAURKAMAPK14 | |
| SCHEMBL438637 | 0.68 | AR (0.47) | HSD17B10KDM4EBRAFPARP15PARP10 | |
| SCHEMBL3069941 | 0.66 | PIK3CD (0.47) | HSD17B10KDM4EGAAPARP15PARP10 | |
| SCHEMBL6953743 | 0.66 | PIK3CD (0.40) | HSD17B10KDM4EMETAP2BRAFPARP15 | |
| SCHEMBL17142230 | 0.66 | KDM4E (0.43) | HSD17B10KDM4EMETAP2BRAFPARP15 | |
| SCHEMBL2457623 | 0.65 | CHEK1 (0.69) | HSD17B10KDM4EMETAP2PARP15PARP10 | |
| SCHEMBL87617 | 0.65 | CYP1A2 (0.59) | HSD17B10GAAGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801726-A | HYDRAZIDE SILICAS | NORTHEASTERN UNIVERSITY (US) | 1989-01-31 | — | — | US | disclosed |