Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 4/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466866 | 0.91 | PLA2G4A (0.44) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL9800395 | 0.89 | PLA2G4A (0.60) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL10494701 | 0.89 | EGFR (0.48) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL10465300 | 0.86 | EGFR (0.57) | EGFRIGF1RFLT4KDRPLA2G2A | |
| SCHEMBL10494798 | 0.84 | HTR6 (0.41) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL10494731 | 0.82 | PLA2G4A (0.53) | PLA2G4A | |
| SCHEMBL9597127 | 0.82 | HTR6 (0.35) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL5918471 | 0.79 | ADRB2 (0.56) | HTR6MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL29043456 | 0.79 | PLA2G2A (0.69) | PLA2G4AEGFRIGF1RFLT4KDR | |
| SCHEMBL31595698 | 0.78 | POLB (0.68) | HRH1HTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816470-A | Heterocyclic compounds | GLAXO GROUP LIMITED | 1989-03-28 | — | — | US | disclosed |
| EP-0145459-A2 | Process for the production of chemical compounds | GLAXO GROUP LIMITED (GB) | 1985-06-19 | — | — | EP | disclosed |