Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 6/20 | 0.35 |
| ▸ | IGF1R | P08069 | 6/20 | 0.35 |
| ▸ | FLT4 | P35916 | 6/20 | 0.35 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10494798 | 0.85 | HTR6 (0.41) | HTR6PLA2G4AEGFRIGF1RFLT4 | |
| SCHEMBL10494723 | 0.82 | PLA2G4A (0.55) | HTR6PLA2G4AEGFRIGF1RFLT4 | |
| SCHEMBL10466866 | 0.82 | PLA2G4A (0.44) | HTR6PLA2G4AEGFRIGF1RFLT4 | |
| SCHEMBL10494701 | 0.81 | EGFR (0.48) | HTR6PLA2G4AEGFRIGF1RFLT4 | |
| SCHEMBL10718886 | 0.81 | ICMT (0.45) | PLA2G4ACNR2CNR1 | |
| SCHEMBL5918471 | 0.80 | ADRB2 (0.56) | HTR6ADRB2HTR1D | |
| Hydrochloric Acid SCHEMBL7558473 | 0.79 | ADRB2 (0.54) | HTR6EGFRIGF1RFLT4KDR | |
| SCHEMBL10465300 | 0.78 | EGFR (0.57) | HTR6EGFRIGF1RFLT4KDR | |
| SCHEMBL10465297 | 0.78 | EGFR (0.53) | HTR6PLA2G4AEGFRIGF1RFLT4 | |
| SCHEMBL9800371 | 0.77 | HTR6 (0.44) | HTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816470-A | Heterocyclic compounds | GLAXO GROUP LIMITED | 1989-03-28 | — | — | US | claimed |
| US-5270333-A | Pharmaceutical | GLAXO GROUP LIMITED (GB) | 1993-12-14 | — | — | US | disclosed |
| WO-1992014708-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500086-A1 | Indole derivatives, their use as medicines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |
| EP-0242939-B1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-05-08 | — | — | EP | disclosed |
| US-4816470-A | Heterocyclic compounds | GLAXO GROUP LIMITED | 1989-03-28 | — | — | US | disclosed |
| EP-0242939-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1987-10-28 | — | — | EP | disclosed |
| EP-0145459-A2 | Process for the production of chemical compounds | GLAXO GROUP LIMITED (GB) | 1985-06-19 | — | — | EP | disclosed |