Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10544372 | 0.85 | RIPK1 (0.51) | TP53LMNARIPK1HSD11B1CYP3A4 | |
| SCHEMBL10546758 | 0.78 | RIPK1 (0.51) | LMNARIPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10546564 | 0.77 | ALDH1A1 (0.51) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL10544009 | 0.75 | ALDH1A1 (0.42) | LMNARIPK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10546095 | 0.75 | KMT2A (0.44) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL10549648 | 0.74 | PDK1 (0.45) | LMNARAB9ATRPM8NPC1ALDH1A1 | |
| SCHEMBL10548744 | 0.73 | MLYCD (0.48) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL21400322 | 0.72 | RIPK1 (0.62) | RIPK1HSD11B1CYP3A4RAB9ACYP2D6 | |
| SCHEMBL6122487 | 0.70 | RIPK1 (0.60) | RIPK1HSD11B1CYP3A4RAB9ACYP2D6 | |
| SCHEMBL10544853 | 0.70 | ALDH1A1 (0.45) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814341-A | HISTAMINE H2 ANTAGONISTS | REITER LAWRENCE A (US) | 1989-03-21 | — | — | US | disclosed |