Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568325 | 0.77 | MEN1 (0.32) | HTR2A | |
| SCHEMBL10563794 | 0.75 | HCAR3 (0.41) | HTR2A | |
| SCHEMBL10567101 | 0.74 | HPGD (0.37) | HPGD | |
| SCHEMBL10567519 | 0.74 | JAK3 (0.38) | LRRK2PRKDC | |
| SCHEMBL15661369 | 0.72 | SRC (0.42) | LRRK2MAP3K8 | |
| SCHEMBL10509852 | 0.69 | MEN1 (0.44) | HPGDTP53 | |
| SCHEMBL10507536 | 0.69 | TGFBR1 (0.40) | HPGDHTR2A | |
| SCHEMBL11412801 | 0.65 | HPGD (0.46) | HPGDTP53 | |
| SCHEMBL11160504 | 0.64 | KDM4E (0.50) | HPGD | |
| SCHEMBL10506617 | 0.61 | SLC2A1 (0.48) | HPGDTP53HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | claimed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | claimed |
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |