Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477754 | 0.81 | NPBWR1 (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10470299 | 0.81 | PDE3B (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10567302 | 0.80 | PDE3B (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10566489 | 0.80 | AURKA (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9834375 | 0.79 | PGR (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10566128 | 0.78 | PDE3B (0.34) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10477810 | 0.78 | TCF4 (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10567103 | 0.77 | PGR (0.37) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10568718 | 0.75 | PDE4A (0.32) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9835975 | 0.75 | CHRNB2 (0.46) | PDE3BPDE3AOPRM1OPRD1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |